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Chromosomal abnormalities in untreated patients with non-Hodgkin's
lymphoma: associations with histology, clinical characteristics, and
treatment outcome. The Nebraska Lymphoma Study Group
HC Schouten, WG Sanger, DD Weisenburger, J Anderson and JO Armitage
Department of Internal Medicine, University of Nebraska Medical Center,
Omaha.
We describe the chromosomal abnormalities found in 104 previously untreated
patients with non-Hodgkin's lymphoma (NHL) and the correlations of these
abnormalities with disease characteristics. The cytogenetic method used was
a 24- to 48-hour culture, followed by G- banding. Several significant
associations were discovered. A trisomy 3 was correlated with high-grade
NHL. In the patients with an immunoblastic NHL, an abnormal chromosome no.
3 or 6 was found significantly more frequently. As previously described, a
t(14;18) was significantly correlated with a follicular growth pattern.
Abnormalities on chromosome no. 17 were correlated with a diffuse histology
and a shorter survival. A shorter survival was also correlated with a +5,
+6, +18, all abnormalities on chromosome no. 5, or involvement of
breakpoint 14q11-12. In a multivariate analysis, these chromosomal
abnormalities appeared to be independent prognostic factors and correlated
with survival more strongly than any traditional prognostic variable.
Patients with a t(11;14)(q13;q32) had an elevated lactate dehydrogenase
(LDH). Skin infiltration was correlated with abnormalities on 2p.
Abnormalities involving breakpoints 6q11-16 were correlated with B
symptoms. Patients with abnormalities involving breakpoints 3q21-25 and
13q21-24 had more frequent bulky disease. The correlations of certain
clinical findings with specific chromosomal abnormalities might help unveil
the pathogenetic mechanisms of NHL and tailor treatment regimens.
Volume 75,
Issue 9,
pp. 1841-1847,
05/01/1990
Copyright © 1990 by The American Society of Hematology
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