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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Skikne, B. S. Articles by Cook, J. D. Search for Related Content PubMed PubMed Citation Articles by Skikne, B. S. Articles by Cook, J. D. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Serum transferrin receptor: a quantitative measure of tissue iron deficiency BS Skikne, CH Flowers and JD Cook Department of Medicine, University of Kansas Medical Center, Kansas City 66103. This study was undertaken to evaluate the role of serum transferrin receptor measurements in the assessment of iron status. Repeated phlebotomies were performed in 14 normal volunteer subjects to obtain varying degrees of iron deficiency. Serial measurements of serum iron, total iron-binding capacity, mean cell volume (MCV), free erythrocyte protoporphyrin (FEP), red cell mean index, serum ferritin, and serum transferrin receptor were performed throughout the phlebotomy program. There was no change in receptor levels during the phase of storage iron depletion. When the serum ferritin level reached subnormal values there was an increase in serum receptor levels, which continued throughout the phlebotomy program. Functional iron deficiency was defined as a reduction in body iron beyond the point of depleted iron stores. The serum receptor level was a more sensitive and reliable guide to the degree of functional iron deficiency than either the FEP or MCV. Our studies indicate that the serum receptor measurement is of particular value in identifying mild iron deficiency of recent onset. The iron status of a population can be fully assessed by using serum ferritin as a measure of iron stores, serum receptor as a measure of mild tissue iron deficiency, and hemoglobin concentration as a measure of advanced iron deficiency. Volume 75, Issue 9, pp. 1870-1876, 05/01/1990 Copyright © 1990 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. Squitti, F. Bressi, P. Pasqualetti, C. Bonomini, R. Ghidoni, G. Binetti, E. Cassetta, F. Moffa, M. Ventriglia, F. Vernieri, et al. Longitudinal prognostic value of serum "free" copper in patients with Alzheimer disease Neurology, January 6, 2009; 72(1): 50 - 55. [Abstract] [Full Text] [PDF] Q. Sun, J. Ma, N. Rifai, O. H. Franco, K. M. Rexrode, and F. B. Hu Excessive Body Iron Stores Are Not Associated with Risk of Coronary Heart Disease in Women J. Nutr., December 1, 2008; 138(12): 2436 - 2441. 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