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The gene for the human erythropoietin receptor: analysis of the coding
sequence and assignment to chromosome 19p
JC Winkelmann, LA Penny, LL Deaven, BG Forget and RB Jenkins
Department of Medicine, University of Minnesota, Minneapolis.
The full-length coding sequence of the human erythropoietin receptor has
been assembled from cDNA and genomic DNA. The derived 508 amino acid
sequence is 82% identical to the murine erythropoietin (Epo) receptor with
one single residue gap in alignment. There is no major structural
difference between the human and murine receptor molecules. Nucleotide
sequence homology is, as expected, very high within the coding domain.
Unexpectedly, there are two distinct, short stretches of 3' untranslated
sequence homology between human and murine cDNAs. The functional
significance of this sequence conservation is unknown. The human Epo
receptor gene is localized to human chromosome 19p by in situ
hybridization. This chromosome assignment is confirmed by hybridization to
a panel of sorted human chromosomes.
Volume 76,
Issue 1,
pp. 24-30,
07/01/1990
Copyright © 1990 by The American Society of Hematology
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