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Tissue factor: identification and characterization of cell types in human
placentae
WP Faulk, CA Labarrere and SD Carson
Division of Experimental Pathology, Methodist Hospital, Indianapolis, IN
46202.
This is an immunohistologic study of tissue factor (TF) in snap frozen,
unfixed, human normal-term placentae. Antibodies to TF were a monoclonal to
human brain TF purified on a factor VII-agarose affinity column, and a
polyclonal to a synthetic polypeptide representing the carboxyl-terminal
nine amino acids of human TF. The results detail the localization and
distribution of TF and characterize the cells in which it is found. TF was
not observed in trophoblast, trophoblastic basement membranes, or
noncellular components of connective tissue. TF was identified in some but
not all macrophages, most fibroblast-like cells, and occasionally in
perivascular cells and endothelium. The most consistent and intense
reactions were obtained with vimentin-positive fibroblast-like cells in
loose connective tissue. TF usually was not identified in fetal stem vessel
endothelial cells, but TF reactivity was found in some of these cells in
chorionic villi with histologic evidence of chronic inflammation. Such
areas are uncommonly found in normal-term placentae. The vast majority of
TF-reactive cells did not react with antibody to factor VII and were not in
contact with blood. The biologic purpose of producing relatively great
amounts of TF in areas remote from circulating factor VII is not known.
Volume 76,
Issue 1,
pp. 86-96,
07/01/1990
Copyright © 1990 by The American Society of Hematology
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