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Levels of serum granulocyte colony-stimulating factor in patients with
infections
M Kawakami, H Tsutsumi, T Kumakawa, H Abe, M Hirai, S Kurosawa, M Mori and M Fukushima
Department of Hematology, Tokyo Metropolitan Geriatric Hospital, Japan.
To clarify the physiologic roles of granulocyte colony-stimulating factor
(G-CSF) in infectious states in vivo, we examined the serum levels of G-CSF
in patients with infection. Serum samples from 24 patients in the acute
stage of infection (14 men and 10 women, age 65 to 101, without hematologic
disorders), as well as samples from 32 age- matched normal elderly
volunteers were investigated. Sixteen of the initial 24 patients were
reexamined after the recovery phase. G-CSF levels were examined by
quantitative enzyme immunoassay. The G-CSF level in normal elderly
controls, 25.3 +/- 19.7 pg/mL, was not different from that reported in
other findings. There was no statistically significant relationship between
their G-CSF level and peripheral white blood cell count or neutrophilic
granulocyte count. The G-CSF level in the acute stage of infection was
731.8 +/- 895.0 pg/mL, with a range of 30 to 3,199 pg/mL. There was no
significant difference in G-CSF levels between patients with respiratory
tract infection and those with urinary tract infection. In all 16 cases
examined, the serum G-CSF level in the acute stage of infection was
significantly higher than that after recovery phase, the latter being the
same as the level in normal elderly controls. G-CSF must therefore play a
significant role in human infectious states in vivo.
Volume 76,
Issue 10,
pp. 1962-1964,
11/15/1990
Copyright © 1990 by The American Society of Hematology
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