|
|
 Previous Article | Table of Contents | Next Article 
Plasma thrombomodulin in health and diseases
S Takano, S Kimura, S Ohdama and N Aoki
First Department of Internal Medicine, Tokyo Medical and Dental University,
Japan.
Sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by
immunoblot analysis of plasma thrombomodulin concentrate revealed that four
degraded forms of thrombomodulin with different molecular weights are
present in plasma. Plasma concentrations of thrombomodulin in patients with
various diseases were measured by two methods of enzyme- linked
immunosorbent assay using monoclonal antibodies. One method measures intact
thrombomodulin and degraded forms of thrombomodulin; the other does not
detect the two smaller degraded forms of thrombomodulin present in plasma.
The results indicated that thrombomodulin was increased in the circulating
blood of patients with disseminated intravascular coagulation syndrome,
pulmonary thromboembolism, adult respiratory distress syndrome, chronic
renal failure, or acute hepatic failure. The different values obtained by
the two methods indicate that the increase of plasma thrombomodulin found
in these patients was mainly due to an increase of the smaller fragments of
degraded forms, suggesting that the release of thrombomodulin from
endothelial cells was accelerated in various disease states by proteolytic
activity generated on the surface of the endothelium and may be removed
from the circulation mostly by the kidneys and liver.
Volume 76,
Issue 10,
pp. 2024-2029,
11/15/1990
Copyright © 1990 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
A. Bouchama, C. Kunzelmann, M. Dehbi, A. Kwaasi, A. Eldali, F. Zobairi, J.-M. Freyssinet, and D. de Prost
Recombinant Activated Protein C Attenuates Endothelial Injury and Inhibits Procoagulant Microparticles Release in Baboon Heatstroke
Arterioscler. Thromb. Vasc. Biol.,
July 1, 2008;
28(7):
1318 - 1325.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Schouten, W. J. Wiersinga, M. Levi, and T. van der Poll
Inflammation, endothelium, and coagulation in sepsis
J. Leukoc. Biol.,
March 1, 2008;
83(3):
536 - 545.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Heilmann, W. Rath, and K. Pollow
Hemostatic Abnormalities in Patients With Severe Preeclampsia
Clinical and Applied Thrombosis/Hemostasis,
July 1, 2007;
13(3):
285 - 291.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. Tanne, R. F. Macko, Y. Lin, B. C. Tilley, S. R. Levine, and for the NINDS rtPA Stroke Study Group
Hemostatic Activation and Outcome After Recombinant Tissue Plasminogen Activator Therapy for Acute Ischemic Stroke
Stroke,
July 1, 2006;
37(7):
1798 - 1804.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-S. Shi, G.-Y. Shi, Y.-S. Chang, H.-S. Han, C.-H. Kuo, C. Liu, H.-C. Huang, Y.-J. Chang, P.-S. Chen, and H.-L. Wu
Evidence of Human Thrombomodulin Domain as a Novel Angiogenic Factor
Circulation,
April 5, 2005;
111(13):
1627 - 1636.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. C. Y. Liaw, C. T. Esmon, K. Kahnamoui, S. Schmidt, S. Kahnamoui, G. Ferrell, S. Beaudin, J. A. Julian, J. I. Weitz, M. Crowther, et al.
Patients with severe sepsis vary markedly in their ability to generate activated protein C
Blood,
December 15, 2004;
104(13):
3958 - 3964.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Sajan, S. S. Da-Silva, and R. P. Dellinger
Drotrecogin Alfa (Activated) in an Infant with Gram-Negative Septic Shock
J Intensive Care Med,
January 1, 2004;
19(1):
51 - 55.
[Abstract]
[PDF]
|
|
|
|
|
|
|
F. Sakamaki, S. Kyotani, N. Nagaya, N. Sato, H. Oya, and N. Nakanishi
Increase in Thrombomodulin Concentrations After Pulmonary Thromboendarterectomy in Chronic Thromboembolic Pulmonary Hypertension
Chest,
October 1, 2003;
124(4):
1305 - 1311.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. B. Ware, X. Fang, and M. A. Matthay
Protein C and thrombomodulin in human acute lung injury
Am J Physiol Lung Cell Mol Physiol,
September 1, 2003;
285(3):
L514 - L521.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. T. Esmon
Coagulation and inflammation
Innate Immunity,
June 1, 2003;
9(3):
192 - 198.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A.-Y. Chong, A.D. Blann, and G.Y.H. Lip
Assessment of endothelial damage and dysfunction: observations in relation to heart failure
QJM,
April 1, 2003;
96(4):
253 - 267.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. T. Esmon
New Mechanisms for Vascular Control of Inflammation Mediated by Natural Anticoagulant Proteins
J. Exp. Med.,
September 2, 2002;
196(5):
561 - 564.
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. M. Conway, M. Van de Wouwer, S. Pollefeyt, K. Jurk, H. Van Aken, A. De Vriese, J. I. Weitz, H. Weiler, P. W. Hellings, P. Schaeffer, et al.
The Lectin-like Domain of Thrombomodulin Confers Protection from Neutrophil-mediated Tissue Damage by Suppressing Adhesion Molecule Expression via Nuclear Factor {kappa}B and Mitogen-activated Protein Kinase Pathways
J. Exp. Med.,
September 2, 2002;
196(5):
565 - 577.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Blank, Y. Shoenfeld, S. Tavor, S. Praprotnik, M. C. Boffa, B. Weksler, M. J. Walenga, J. Amiral, and A. Eldor
Anti-platelet factor 4/heparin antibodies from patients with heparin-induced thrombocytopenia provoke direct activation of microvascular endothelial cells
Int. Immunol.,
February 1, 2002;
14(2):
121 - 129.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Stearns-Kurosawa, K. Swindle, A. D'Angelo, P. Della Valle, A. Fattorini, N. Caron, M. Grimaux, B. Woodhams, and S. Kurosawa
Plasma levels of endothelial protein C receptor respond to anticoagulant treatment
Blood,
January 15, 2002;
99(2):
526 - 530.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Borawski, B. Naumnik, and M. Mys'liwiec
Increased Soluble Thrombomodulin Does Not Always Indicate Endothelial Injury
Clinical and Applied Thrombosis/Hemostasis,
January 1, 2002;
8(1):
87 - 89.
[PDF]
|
|
|
|
|
|
|
J. Borawski, B. Naumnik, K. Pawlak, and M. Mysliwiec
Soluble thrombomodulin is associated with viral hepatitis, blood pressure, and medications in haemodialysis patients
Nephrol. Dial. Transplant.,
April 1, 2001;
16(4):
787 - 792.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Praprotnik, M. Blank, Y. Levy, S. Tavor, M.-C. Boffa, B. Weksler, A. Eldor, and Y. Shoenfeld
Anti-endothelial cell antibodies from patients with thrombotic thrombocytopenic purpura specifically activate small vessel endothelial cells
Int. Immunol.,
February 1, 2001;
13(2):
203 - 210.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Bhattacharya and M. L. Cohen
Vascular Contraction and Relaxation to Thrombin and Trypsin: Thrombomodulin Preferentially Attenuates Thrombin-Induced Contraction
J. Pharmacol. Exp. Ther.,
October 1, 2000;
295(1):
284 - 290.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
T. Sato, T. Miwa, H. Akatsu, N. Matsukawa, K. Obata, N. Okada, W. Campbell, and H. Okada
Pro-Carboxypeptidase R is an Acute Phase Protein in the Mouse, Whereas Carboxypeptidase N Is Not
J. Immunol.,
July 15, 2000;
165(2):
1053 - 1058.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. B. Taylor Jr, D. J. Stearns-Kurosawa, S. Kurosawa, G. Ferrell, A. C. K. Chang, Z. Laszik, S. Kosanke, G. Peer, and C. T. Esmon
The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis
Blood,
March 1, 2000;
95(5):
1680 - 1686.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Xu, D. Qu, N. L. Esmon, and C. T. Esmon
Metalloproteolytic Release of Endothelial Cell Protein C Receptor
J. Biol. Chem.,
February 25, 2000;
275(8):
6038 - 6044.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. T. Esmon
Introduction: are natural anticoagulants candidates for modulating the inflammatory response to endotoxin?
Blood,
February 15, 2000;
95(4):
1113 - 1116.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S Kiraz, I Ertenli, M Benekli, I C Haznedarogul, M Calguneri, I Celik, S Apras, and S Kirazlil
Clinical significance of hemostatic markers and thrombomodulin in systemic lupus erythematosus: evidence for a prothrombotic state
Lupus,
November 1, 1999;
8(9):
737 - 741.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. Veyssier-Belot and P. Cacoub
Role of endothelial and smooth muscle cells in the physiopathology and treatment management of pulmonary hypertension
Cardiovasc Res,
November 1, 1999;
44(2):
274 - 282.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N M Al-Saady, E W Leatham, S Gupta, J T C Kwan, J B Eastwood, and C A Seymour
Monocyte expression of tissue factor and adhesion molecules: the link with accelerated coronary artery disease in patients with chronic renal failure
Heart,
February 1, 1999;
81(2):
134 - 140.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. L. Randi, C. Meneghin, P. Zerbinati, A. Sbarai, E. Rampin, R. Pasini, L. Zanin, A. Girolami, and G. Cella
Soluble Plasma Thrombomodulin Levels in Patients with Chronic Myeloproliferative Disorder
Clinical and Applied Thrombosis/Hemostasis,
January 1, 1999;
5(1):
43 - 47.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G. Tohda, K. Oida, Y. Okada, S. Kosaka, E. Okada, S. Takahashi, H. Ishii, and I. Miyamori
Expression of Thrombomodulin in Atherosclerotic Lesions and Mitogenic Activity of Recombinant Thrombomodulin in Vascular Smooth Muscle Cells
Arterioscler. Thromb. Vasc. Biol.,
December 1, 1998;
18(12):
1861 - 1869.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. MIYAZAKI, T. INOUE, M. KYI, M. SAWADA, S. MIYAKE, and Y. YOSHIZAWA
Effects of a Neutrophil Elastase Inhibitor (ONO-5046) on Acute Pulmonary Injury Induced by Tumor Necrosis Factor Alpha (TNFalpha ) and Activated Neutrophils in Isolated Perfused Rabbit Lungs
Am. J. Respir. Crit. Care Med.,
January 1, 1998;
157(1):
89 - 94.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M-C. Boffa and M. Karmochkine
Review : Thrombomodulin: an overview and potential implications in vascular disorders
Lupus,
January 1, 1998;
7(2_suppl):
S120 - S125.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. Boldt, C. Knothe, I. Welters, F. L. Dapper, and G. Hempelmann
Normothermic Versus Hypothermic Cardiopulmonary Bypass: Do Changes in Coagulation Differ?
Ann. Thorac. Surg.,
July 1, 1996;
62(1):
130 - 135.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. R. Rezaie, S. T. Cooper, F. C. Church, and C. T. Esmon
Protein C Inhibitor Is a Potent Inhibitor of the Thrombin-Thrombomodulin Complex
J. Biol. Chem.,
October 27, 1995;
270(43):
25336 - 25339.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F.-J. Neumann, I. Ott, M. Gawaz, G. Richardt, H. Holzapfel, M. Jochum, and A. Schomig
Cardiac Release of Cytokines and Inflammatory Responses in Acute Myocardial Infarction
Circulation,
August 15, 1995;
92(4):
748 - 755.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. Boldt, B. Zickmann, E.Schindler, A. Welters, F. Dapper, and G. Hempelmann
Influence of aprotinin on the thrombomodulin/ protein C system in pediatric cardiac operations
J. Thorac. Cardiovasc. Surg.,
May 1, 1994;
107(5):
1215 - 1221.
[Abstract]
[Full Text]
|
|
|
|
|
