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Expression of P-glycoprotein in adult T-cell leukemia cells
Y Kuwazuru, S Hanada, T Furukawa, A Yoshimura, T Sumizawa, A Utsunomiya, K Ishibashi, T Saito, K Uozumi and M Maruyama
Cancer Research Institute, Kagoshima University, Japan.
We have examined the expression of P-glycoprotein (P-gp) in adult T- cell
leukemia (ATL) samples from 25 patients. Based on immunoblotting with a
monoclonal antibody against P-gp, C219, 8 of 20 ATL patients were P-gp
positive at the initial presentation. All 6 patients at the relapsed stage
were P-gp positive, and refractory to chemotherapy. The expression of MDR1
mRNA in P-gp-positive ATL cells was increased at the relapsed stage of one
patient. P-gp of this patient was photolabeled with [3H]azidopine and the
labeling was inhibited with nimodipine, vinblastine and progesterone. These
results suggest that P-gp expressed in ATL cells from patients at relapsed
stage has the same binding site(s) for the drugs as that in multidrug
resistant cells, and is correlated with the refractory nature of the cells
to chemotherapy.
Volume 76,
Issue 10,
pp. 2065-2071,
11/15/1990
Copyright © 1990 by The American Society of Hematology
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