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Association of bcl-1 rearrangements with lymphocytic lymphoma of
intermediate differentiation
LJ Medeiros, JH Van Krieken, ES Jaffe and M Raffeld
Hematopathology Section, National Cancer Institute, National Institutes of
Health, Bethesda, MD 20892.
Previous studies using classical cytogenetics have demonstrated the
presence of the t(11;14) (q13;q32) chromosomal translocation in some cases
of lymphocytic lymphoma of intermediate differentiation (IDL), a distinct
type of low grade B-cell lymphoma. This finding suggested that the bcl-1
region (located at band q13 of chromosome 11) might be involved in this
neoplasm. Using a genomic probe from the major breakpoint area of the bcl-1
locus, we identified rearrangements of the bcl-1 region in 10 of 19 cases,
2 of which comigrated with a rearranged allele of the immunoglobulin heavy
chain gene joining region. In contrast, bcl-1 rearrangements were not found
in other types of low grade B-cell lymphoma, specifically in 36 cases of
chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and 27
cases of follicular lymphoma (FL). To further assess the molecular
pathology of IDL, we analyzed these cases for rearrangements of the bcl-2
proto- oncogene, which is associated primarily with follicular lymphomas.
None of the 19 cases of IDL had rearrangements. Furthermore, none of the 36
cases of CLL/SLL showed bcl-2 rearrangements, whereas, as expected, 21 of
27 cases of FL had rearrangements of the bcl-2 locus. Our findings
demonstrate an association between a rearranged bcl-1 region with
approximately 50% of IDLs and suggest that abnormalities of this locus may
be important in the pathogenesis of IDL.
Volume 76,
Issue 10,
pp. 2086-2090,
11/15/1990
Copyright © 1990 by The American Society of Hematology
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