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Highly increased production of bone marrow-derived blood cells by administration of homologous interleukin-3 to rhesus monkeys

G Wagemaker, FC van Gils, H Burger, LC Dorssers, RW van Leen, NL Persoon, JJ Wielenga, JL Heeney and E Knol

Institute Radiobiology, Erasmus University, Amsterdam, The Netherlands.

Recombinant rhesus monkey interleukin-3 (IL-3) was administered to normal rhesus monkeys in graded doses ranging from 3 to 30 micrograms/kg/d subcutaneously for 30 consecutive days or given as a continuous intravenous infusion at a dose of 30 micrograms/kg/d for 16 days. After a lag phase of about 1 week, a highly increased, dose- dependent production of bone marrow-derived blood cells was observed, preceded by amplification of bone marrow hematopoietic progenitor cells. Simultaneously, peripheral blood progenitor cells rose. The increase included basophilic, eosinophilic and neutrophilic granulocytes, monocytes, and the erythrocyte and platelet lineages. Characteristically, a T-lymphocyte response was absent. It is concluded that IL-3 in vivo stimulates blood cell production from an immature, multipotent progenitor cell.

Volume 76, Issue 11, pp. 2235-2241, 12/01/1990
Copyright © 1990 by The American Society of Hematology


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  Copyright © 1990 by American Society of Hematology         Online ISSN: 1528-0020