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Highly increased production of bone marrow-derived blood cells by
administration of homologous interleukin-3 to rhesus monkeys
G Wagemaker, FC van Gils, H Burger, LC Dorssers, RW van Leen, NL Persoon, JJ Wielenga, JL Heeney and E Knol
Institute Radiobiology, Erasmus University, Amsterdam, The Netherlands.
Recombinant rhesus monkey interleukin-3 (IL-3) was administered to normal
rhesus monkeys in graded doses ranging from 3 to 30 micrograms/kg/d
subcutaneously for 30 consecutive days or given as a continuous intravenous
infusion at a dose of 30 micrograms/kg/d for 16 days. After a lag phase of
about 1 week, a highly increased, dose- dependent production of bone
marrow-derived blood cells was observed, preceded by amplification of bone
marrow hematopoietic progenitor cells. Simultaneously, peripheral blood
progenitor cells rose. The increase included basophilic, eosinophilic and
neutrophilic granulocytes, monocytes, and the erythrocyte and platelet
lineages. Characteristically, a T-lymphocyte response was absent. It is
concluded that IL-3 in vivo stimulates blood cell production from an
immature, multipotent progenitor cell.
Volume 76,
Issue 11,
pp. 2235-2241,
12/01/1990
Copyright © 1990 by The American Society of Hematology
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