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Transforming growth factor beta downregulates interleukin-1 (IL-1)- induced IL-6 production by human monocytes

T Musso, I Espinoza-Delgado, K Pulkki, GL Gusella, DL Longo and L Varesio

Program Resources, Inc, National Cancer Institute, Frederick, MD.

We investigated the effects of transforming growth factor beta (TGF beta) on the induction by interleukin-1 beta (IL-1 beta) of IL-6 in human monocytes. We found that IL-1 beta induced IL-6 messenger RNA expression in elutriated monocytes and IL-6 secretion in the supernatant. TGF beta did not induce IL-6. In contrast, TGF beta added to the culture inhibited, in a dose-dependent manner, the induction of IL-6 by IL-1 at the level of messenger RNA and bioactivity. These results show that IL-1 beta is able to stimulate IL-6 production by monocytes, TGF beta, by inhibiting this effect, may play an important role in regulating the IL-1-mediated components of the inflammatory response.

Volume 76, Issue 12, pp. 2466-2469, 12/15/1990
Copyright © 1990 by The American Society of Hematology


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