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Immunity against Pseudomonas aeruginosa adoptively transferred to bone
marrow transplant recipients
DJ Gottlieb, SJ Cryz , E Furer, JU Que, HG Prentice, AS Duncombe and MK Brenner
Department of Haematology, Royal Free Hospital, London, UK.
Infection is a common problem for bone marrow transplant (BMT) recipients
during the period of neutropenia that immediately follows the procedure.
Gram-negative infections present a particular hazard in these
immunocompromised hosts. To augment host defenses against one such
pathogen, Pseudomonas aeruginosa, we immunized bone marrow transplant
donors and/or recipients with a polyvalent O-polysaccharide- toxin A
conjugate vaccine. When either donor or recipient alone was vaccinated
before transplant, no increase in specific antibody titers to any of the
vaccine components was observed in the recipient. However, when both donor
and recipient were vaccinated before transplant, increases in antibody
titers to all polysaccharide components occurred to levels shown to be
protective in animal models of gram-negative sepsis. Specific antibodies
were primarily of the IgG1 and IgG2 subclass even though IgG2 subclass
deficiency is common after BMT. The requirement for both donor and
recipient immunization reflects the need for primed donor B lymphocytes in
the marrow inoculum to be transferred into an antigen-containing
environment so that maximum B- cell proliferation and antibody secretion
can occur. Adoptive transfer of antibody responses to Pseudomonas
aeruginosa and other common bacterial pathogens has the potential to reduce
infection-related morbidity and mortality after allogeneic bone marrow
transplantation.
Volume 76,
Issue 12,
pp. 2470-2475,
12/15/1990
Copyright © 1990 by The American Society of Hematology
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