|
|
 Previous Article | Table of Contents | Next Article 
Activation of the interleukin-3 gene by chromosome translocation in acute
lymphocytic leukemia with eosinophilia [see comments]
TC Meeker, D Hardy, C Willman, T Hogan and J Abrams
Department of Medicine, University of California, San Francisco.
The t(5;14)(q31;q32) translocation from B-lineage acute lymphocytic
leukemia with eosinophilia has been cloned from two leukemia samples. In
both cases, this translocation joined the IgH gene and the interleukin-3
(IL-3) gene. In one patient, excess IL-3 mRNA was produced by the leukemic
cells. In the second patient, serum IL-3 levels were measured and shown to
correlate with disease activity. There was no evidence of excess
granulocyte/macrophage colony stimulating factor (GM-CSF) or IL-5
expression. Our data support the formulation that this subtype of leukemia
may arise in part because of a chromosome translocation that activates the
IL-3 gene, resulting in autocrine and paracrine growth effects.
Volume 76,
Issue 2,
pp. 285-289,
07/15/1990
Copyright © 1990 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
L. J. Russell, T. Akasaka, A. Majid, K.-j. Sugimoto, E. Loraine Karran, I. Nagel, L. Harder, A. Claviez, S. Gesk, A. V. Moorman, et al.
t(6;14)(p22;q32): a new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
Blood,
January 1, 2008;
111(1):
387 - 391.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Akasaka, T. Balasas, L. J. Russell, K.-j. Sugimoto, A. Majid, R. Walewska, E. L. Karran, D. G. Brown, K. Cain, L. Harder, et al.
Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
Blood,
April 15, 2007;
109(8):
3451 - 3461.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Huang and R. P. Hasserjian
Case 19-2004 - A 12-Year-Old Boy with Fatigue and Eosinophilia
N. Engl. J. Med.,
June 17, 2004;
350(25):
2604 - 2612.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Gotlib, J. Cools, J. M. Malone III, S. L. Schrier, D. G. Gilliland, and S. E. Coutre
The FIP1L1-PDGFR{alpha} fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management
Blood,
April 15, 2004;
103(8):
2879 - 2891.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Cools, N. Mentens, M. D. Odero, P. Peeters, I. Wlodarska, M. Delforge, A. Hagemeijer, and P. Marynen
Evidence for position effects as a variant ETV6-mediated leukemogenic mechanism in myeloid leukemias with a t(4;12)(q11-q12;p13) or t(5;12)(q31;p13)
Blood,
March 1, 2002;
99(5):
1776 - 1784.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Di Bacco, K. Keeshan, S. L. McKenna, and T. G. Cotter
Molecular Abnormalities in Chronic Myeloid Leukemia: Deregulation of Cell Growth and Apoptosis
Oncologist,
October 1, 2000;
5(5):
405 - 415.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
T. G. Willis and M. J. S. Dyer
The role of immunoglobulin translocations in the pathogenesis of B-cell malignancies
Blood,
August 1, 2000;
96(3):
808 - 822.
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. E. Ailles, B. Gerhard, H. Kawagoe, and D. E. Hogge
Growth Characteristics of Acute Myelogenous Leukemia Progenitors That Initiate Malignant Hematopoiesis in Nonobese Diabetic/Severe Combined Immunodeficient Mice
Blood,
September 1, 1999;
94(5):
1761 - 1772.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. P. K. Nair, H. H. Hirsch, M. Colombi, and C. Moroni
Cyclosporin A Promotes Translational Silencing of Autocrine Interleukin-3 via Ribosome-Associated Deadenylation
Mol. Cell. Biol.,
January 1, 1999;
19(1):
889 - 898.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Abe, N. Emi, M. Tanimoto, H. Terasaki, T. Marunouchi, and H. Saito
Fusion of the Platelet-Derived Growth Factor Receptor beta to a Novel Gene CEV14 in Acute Myelogenous Leukemia After Clonal Evolution
Blood,
December 1, 1997;
90(11):
4271 - 4277.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Ikushima, T. Inukai, T. Inaba, S. D. Nimer, J. L. Cleveland, and A. T. Look
Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes
PNAS,
March 18, 1997;
94(6):
2609 - 2614.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Wlodarska, A. Aventin, J. Ingles-Esteve, D. Falzetti, A. Criel, J.-J. Cassiman, C. Mecucci, H. Van den Berghe, and P. Marynen
A New Subtype of Pre-B Acute Lymphoblastic Leukemia With t(5; 12)(q31q33; p12), Molecularly and Cytogenetically Distinct From t(5; 12) in Chronic Myelomonocytic Leukemia
Blood,
March 1, 1997;
89(5):
1716 - 1722.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. B. Gorlin and J. A. Ferry
Case 26-1996- A Seven-Year-Old-Boy with Fever, Lymphadenopathy, Hepatosplenomegaly, and Prominent Eosinophilia
N. Engl. J. Med.,
August 22, 1996;
335(8):
577 - 584.
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. H. Hirsch, A. P. K. Nair, V. Backenstoss, and C. Moroni
Interleukin-3 mRNA Stabilization by a trans-Acting Mechanism in Autocrine Tumors Lacking Interleukin-3 Gene Rearrangements
J. Biol. Chem.,
September 1, 1995;
270(35):
20629 - 20635.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Cline
The Molecular Basis of Leukemia
N. Engl. J. Med.,
February 3, 1994;
330(5):
328 - 336.
[Full Text]
|
|
|
|
|
|
|
E Solomon, J Borrow, and A. Goddard
Chromosome aberrations and cancer
Science,
November 22, 1991;
254(5035):
1153 - 1160.
[Abstract]
[PDF]
|
|
|
|
|
