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In vivo administration of antibody to interleukin-5 inhibits increased
generation of eosinophils and their progenitors in bone marrow of
parasitized mice
DM Rennick, L Thompson-Snipes, RL Coffman, BW Seymour, JD Jackson and S Hudak
Department of Immunology, DNAX Research Institute of Molecular and Cellular
Biology, Palo Alto, CA 94304.
Bone marrow of mice parasitized with Nippostrongylus brasiliensis showed
increased numbers of eosinophils as early as 4 days after infection. By day
7, their bone marrow also contained elevated numbers of progenitors that
form small eosinophil colonies (20 to 50 cells) in soft agar cultures
supplemented with interleukin-5 (IL-5). However, when mice were infused
with anti-IL-5 antibodies at the time of infection, the number of
recognizable eosinophils present in bone marrow remained low and eventually
dropped below normal levels. The antibody treatment also prevented
increased generation of IL-5- responsive precursors capable of
differentiating into mature eosinophils in liquid culture and inhibited the
generation of progenitor cells capable of forming small eosinophil colonies
or clusters in soft agar cultures. The results of these in vivo experiments
directly show that IL-5 is an essential regulatory molecule required for
the bone marrow-dependent phase of a parasite-induced eosinophilia.
Volume 76,
Issue 2,
pp. 312-316,
07/15/1990
Copyright © 1990 by The American Society of Hematology
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