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Human immunodeficiency virus infection of human bone marrow stromal
fibroblasts
DT Scadden, M Zeira, A Woon, Z Wang, L Schieve, K Ikeuchi, B Lim and JE Groopman
Division of Hematology/Oncology, New England Deaconess Hospital, Harvard
Medical School, Boston, MA 02215.
The human immunodeficiency virus (HIV) preferentially infects CD4 positive
T cells and monocytes. Other human cell types have been reported to be
infectable with HIV, including cells of mesenchymal origin. In this report,
we show that both primary human bone marrow stromal fibroblasts and an
immortalized human stromal fibroblast line are susceptible to HIV
infection. These cells are capable of passing HIV to cells of lymphoid or
myeloid lineage, and may thereby act as a reservoir of virus. This in vitro
system may be a useful model for assessing the pathophysiology of
hematopoietic dysfunction in AIDS patients.
Volume 76,
Issue 2,
pp. 317-322,
07/15/1990
Copyright © 1990 by The American Society of Hematology
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