Effects of recombinant human granulocyte colony-stimulating factor on the
hematologic recovery and survival of irradiated mice
S Tanikawa, M Nose, Y Aoki, K Tsuneoka, M Shikita and N Nara
Division of Radiation Health, National Institute of Radiological Sciences,
Chiba, Japan.
We studied the effects of intraperitoneal injections of recombinant human
granulocyte colony-stimulating factor (rhG-CSF) according to various
administration schedules on the recovery of spleen colony- forming units
(CFU-S) and peripheral blood counts, and on the survival of irradiated
mice. The sooner and more frequently the mice were injected with rhG-CSF
after irradiation, the more enhanced the recovery of CFU-S in bone marrow
was obtained on day 7. Twice-daily injections of rhG-CSF from day 0 to day
2 significantly enhanced the recovery of platelets and hematocrit, but two
injections of rhG-CSF on only day 0 did not. Twice-daily injections of
rhG-CSF from day 0 to day 6 enhanced the recovery of platelets more
effectively than twice-daily injections of rhG-CSF from day 1 to day 7, and
increased the survival of irradiated mice more effectively than any other
examined administration schedules. Twice-daily injections of rhG-CSF from
day 0 to day 6 were significantly effective in enhancing the survival of
mice irradiated with 8.5-, 9.0-, and 9.5-Gy x-rays, although not effective
after irradiation of 10.5-Gy x-rays.
Volume 76,
Issue 3,
pp. 445-449,
08/01/1990
Copyright © 1990 by The American Society of Hematology
