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Molecular genetics of gastrointestinal non-Hodgkin's lymphomas: unusual
prevalence and pattern of c-myc rearrangements in aggressive lymphomas
JH van Krieken, M Raffeld, S Raghoebier, ES Jaffe, GJ van Ommen and PM Kluin
Department of Pathology, University of Leiden, The Netherlands.
Thirty-two extranodal lymphomas of the gastrointestinal (GI) tract
underwent molecular genetic analysis by Southern blotting using probes for
the immunoglobulin genes and the bcl-1, bcl-2, and c-myc loci, commonly
involved in lymphomagenesis. No bcl-1 rearrangements were found. There was
only one large-cell lymphoma with a bcl-2 rearrangement. A rearrangement of
the c-myc gene was found in six of eight Burkittlike lymphomas of the
intestine. In five of these six cases, a chromosomal translocation t(8;14)
with an unusual breakpoint was demonstrated by comigration of the
rearranged c-myc and a rearranged JH sequence. This pattern of
rearrangement has not been previously associated with a specific group of
non-Hodgkin's lymphomas. In contrast to all six low-grade lymphomas, c-myc
rearrangements were found in 6 of 12 large-cell or high-grade
mucosa-associated lymphomas of the stomach. No comigration of c-myc and
immunoglobulin heavy-chain gene sequences were found. We conclude that
primary GI lymphomas have different molecular genetic characteristics
compared with node-based follicle center-cell lymphoma and as a group are
not related to these lymphomas. In addition, the prevalence and patterns of
c-myc rearrangements in the gastric large-cell lymphomas and ileocecal
Burkittlike lymphomas are noteworthy and suggest a different and distinct
pathogenesis for these tumors.
Volume 76,
Issue 4,
pp. 797-800,
08/15/1990
Copyright © 1990 by The American Society of Hematology
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