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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Rozman, C. Articles by Climent, C. Search for Related Content PubMed PubMed Citation Articles by Rozman, C. Articles by Climent, C. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Variations of fat tissue fraction in abnormal human bone marrow depend both on size and number of adipocytes: a stereologic study C Rozman, JC Reverter, E Feliu, L Berga, M Rozman and C Climent Postgraduate School of Haematology Farreras Valenti, Hospital Clinic, University of Barcelona, Spain. Studies dealing with the number or size of individual adipose cells in abnormal human bone marrow are lacking. To ascertain whether variations in fat tissue fraction depend on the size of individual adipocytes or their number or both, a stereologic study of 30 human bone marrow specimens (10 with aplasia, 10 with hyperplasia, and 10 with dysplasia) was performed. A total of 23,435 adipocyte profiles were measured and two stereologic parameters were obtained in each specimen: mean diameter and number of cells per mm3 of bone marrow. The fat tissue fraction correlated positively with the size (r = .79; P less than .001) and the number/volume (r = .77; P less than .001) of adipocytes. The significance of both adipocyte size and adipocyte number/volume was confirmed by stepwise multiple regression, in which the size alone explained 62.5% of fat tissue fraction and both size and number/volume explained 95.8% of fat tissue fraction. These results are discussed from a pathophysiologic point of view. Volume 76, Issue 5, pp. 892-895, 09/01/1990 Copyright © 1990 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. P. Shah, P. W. Patton, D. A. Rajon, and W. E. Bolch Adipocyte Spatial Distributions in Bone Marrow: Implications for Skeletal Dosimetry Models J. Nucl. Med., May 1, 2003; 44(5): 774 - 783. [Abstract] [Full Text] [PDF]

	Copyright © 1990 by American Society of Hematology         Online ISSN: 1528-0020