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T-cell growth factor P40 promotes the proliferation of myeloid cell lines
and enhances erythroid burst formation by normal murine bone marrow cells
in vitro
DE Williams, PJ Morrissey, DY Mochizuki, P de Vries, D Anderson, D Cosman, HS Boswell, S Cooper, KH Grabstein and HE Broxmeyer
Department of Experimental Hematology, Immunex Corporation, Seattle, WA
98101.
T-cell growth factor P40 was examined for possible effects on murine
interleukin-3 (IL-3)-dependent myeloid cell lines and freshly isolated
murine bone marrow cells. The results showed that P40 stimulated the
proliferation of some IL-3-dependent myeloid cell lines of both early
myeloid and mast cell phenotype and synergized with IL-3. P40 did not
promote proliferation of fresh bone marrow cells, bone marrow enriched for
early myeloid cells by 5-fluorouracil treatment, or bone marrow derived
mast cells as assessed in 3H-TdR incorporation assays. P40 did not
influence the growth of murine colony-forming unit granulocyte- macrophage
in agar cultures, either alone or in the presence of optimal or sub-optimal
concentrations of CSF-1, GM-colony-stimulating factor, or IL-3. P40 did
potentiate burst-forming unit-erythroid (BFU-E) formation in the presence
of erythropoietin; however, this was dependent on the cell plating density,
suggesting an indirect stimulation of BFU-E by P40. The indirect nature of
P40 action on BFU-E was further demonstrated in cell separation experiments
and indicated that the effect was mediated by T cells. These data expand
the repertoire of cells that P40 influences.
Volume 76,
Issue 5,
pp. 906-911,
09/01/1990
Copyright © 1990 by The American Society of Hematology
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