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Kaposi's sarcoma in human T-cell leukemia virus type I-associated adult T-cell leukemia

SJ Greenberg, ES Jaffe, GD Ehrlich, NJ Korman, BJ Poiesz and TA Waldmann

Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

Kaposi's sarcoma (KS) developed in a patient with human T-cell leukemia virus type I (HTLV-I)-associated adult T-cell leukemia who was treated with a short-term course of monoclonal antibody immunotherapy. The presentation was transient and temporally related to the underlying clinical course. The association of KS in an HTLV-I infected, but not human immunodeficiency virus (HIV)-infected, individual should alert investigators to the occurrence of KS in retroviral-associated diseases other than acquired immunodeficiency disease syndrome. Recognition of the similarities and differences between HTLV-I and HIV infections may provide insights concerning the angiopathogenesis of KS.

Volume 76, Issue 5, pp. 971-976, 09/01/1990
Copyright © 1990 by The American Society of Hematology


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