|
|
 Previous Article | Table of Contents | Next Article 
Enhancing and suppressing effects of recombinant murine macrophage
inflammatory proteins on colony formation in vitro by bone marrow myeloid
progenitor cells
HE Broxmeyer, B Sherry, L Lu, S Cooper, KO Oh, P Tekamp-Olson, BS Kwon and A Cerami
Department of Medicine (Hematology/Oncology), Indiana University School of
Medicine, Indianapolis.
Purified recombinant (r) macrophage inflammatory proteins (MIPs) 1 alpha, 1
beta, and 2 were assessed for effects on murine (mu) and human (hu) marrow
colony-forming unit-granulocyte-macrophage (CFU-GM) and burst-forming
unit-erythroid (BFU-E) colonies. Recombinant MIP-1 alpha, -1 beta, and -2
enhanced muCFU-GM colonies above that stimulated with 10 to 100 U natural
mu macrophage-colony-stimulating factor (M-CSF) or rmuGM-CSF, with
enhancement seen on huCFU-GM colony formation stimulated with suboptimal
rhuM-CSF or rhuGM-CSF; effects were neutralized by respective MIP-specific
antibodies. Macrophage inflammatory proteins had no effects on mu or
huBFU-E colonies stimulated with erythropoietin (Epo). However, natural
MIP-1 and rMIP-1 alpha, but not rMIP-1 beta or -2, suppressed muCFU-GM
stimulated with pokeweed mitogen spleen-conditioned medium (PWMSCM),
huCFU-GM stimulated with optimal rhuGM-CSF plus rhu interleukin-3 (IL-3),
muBFU- E and multipotential progenitors (CFU-GEMM) stimulated with Epo plus
PWMSCM, and huBFU-E and CFU-GEMM stimulated with Epo plus rhuIL-3 or
rhuGM-CSF. The suppressive effects of natural MIP-1 and rMIP-1 alpha were
also apparent on a population of BFU-E, CFU-GEMM, and CFU-GM present in
cell-sorted fractions of human bone marrow (CD34 HLA-DR+) highly enriched
for progenitors with cloning efficiencies of 42% to 75%. These results,
along with our previous studies, suggest that MIP-1 alpha, -1 beta, and -2
may have direct myelopoietic enhancing activity for mature progenitors,
while MIP-1 alpha may have direct suppressing activity for more immature
progenitors.
Volume 76,
Issue 6,
pp. 1110-1116,
09/15/1990
Copyright © 1990 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M. Iwata, M. Pillai, A. Ramakrishnan, R. C. Hackman, H. J. Deeg, G. Opdenakker, and B. Torok-Storb
Reduced expression of inducible gelatinase B/matrix metalloproteinase-9 in monocytes from patients with myelodysplastic syndrome: correlation of inducible levels with the percentage of cytogenetically marked cells and with marrow cellularity
Blood,
January 1, 2007;
109(1):
85 - 92.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Wimmer, S. K. Khaldoyanidi, M. Judex, N. Serobyan, R. G. DiScipio, and I. U. Schraufstatter
CCL18/PARC stimulates hematopoiesis in long-term bone marrow cultures indirectly through its effect on monocytes
Blood,
December 1, 2006;
108(12):
3722 - 3729.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Ottersbach, J. Mclean, N. W. Isaacs, and G. J. Graham
A310 helical turn is essential for the proliferation-inhibiting properties of macrophage inflammatory protein-1 alpha (CCL3)
Blood,
February 15, 2006;
107(4):
1284 - 1291.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Hadjur and F. R. Jirik
Increased sensitivity of Fancc-deficient hematopoietic cells to nitric oxide and evidence that this species mediates growth inhibition by cytokines
Blood,
May 15, 2003;
101(10):
3877 - 3884.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Lamkhioued, S. G. Abdelilah, Q. Hamid, N. Mansour, G. Delespesse, and P. M. Renzi
The CCR3 Receptor Is Involved in Eosinophil Differentiation and Is Up-Regulated by Th2 Cytokines in CD34+ Progenitor Cells
J. Immunol.,
January 1, 2003;
170(1):
537 - 547.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. K. Lee, E. H. Lee, Y. P. Yun, K. Kim, K. Kwack, D. S. Na, B. S. Kwon, and C.-K. Lee
Truncation of NH2-terminal Amino Acid Residues Increases Agonistic Potency of Leukotactin-1 on CC Chemokine Receptors 1 and 3
J. Biol. Chem.,
April 19, 2002;
277(17):
14757 - 14763.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Cashman, I. Clark-Lewis, A. Eaves, and C. Eaves
Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice
Blood,
February 1, 2002;
99(3):
792 - 799.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. C. Anderson, J. D. Shaughnessy Jr., B. Barlogie, J.-L. Harousseau, and G. D. Roodman
Multiple Myeloma
Hematology,
January 1, 2002;
2002(1):
214 - 240.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
K. Ottersbach, D. N. Cook, W. A. Kuziel, A. Humbles, B. Lu, C. Gerard, A. E. I. Proudfoot, and G. J. Graham
Macrophage inflammatory protein-1alpha uses a novel receptor for primitive hemopoietic cell inhibition
Blood,
December 1, 2001;
98(12):
3476 - 3478.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M Nazareth, P Fanti, C Schwach, K Poppenberg, K Janis, and S M Aronica
Altered Bax expression and decreased apoptosis in bone marrow cells of lupus-susceptible NZB/W mice
Lupus,
November 1, 2001;
10(11):
785 - 793.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. M. Lindell, T. J. Standiford, P. Mancuso, Z. J. Leshen, and G. B. Huffnagle
Macrophage Inflammatory Protein 1{alpha}/CCL3 Is Required for Clearance of an Acute Klebsiella pneumoniae Pulmonary Infection
Infect. Immun.,
October 1, 2001;
69(10):
6364 - 6369.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. A. de Wynter, C. M. Heyworth, N. Mukaida, E. Jaworska, A. Weffort-Santos, K. Matushima, and N. G. Testa
CCR1 chemokine receptor expression isolates erythroid from granulocyte-macrophage progenitors
J. Leukoc. Biol.,
September 1, 2001;
70(3):
455 - 460.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S M Aronica, A Dozier, P Fanti, and M Nazareth
Altered bone marrow cell sensitivity in the lupus-prone NZB/W mouse: regulation of CFU-GM colony formation by estrogen, tamoxifen and thrombopoietin
Lupus,
May 1, 2000;
9(4):
271 - 277.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. A. Martiney, B. Sherry, C. N. Metz, M. Espinoza, A. S. Ferrer, T. Calandra, H. E. Broxmeyer, and R. Bucala
Macrophage Migration Inhibitory Factor Release by Macrophages after Ingestion of Plasmodium chabaudi-Infected Erythrocytes: Possible Role in the Pathogenesis of Malarial Anemia
Infect. Immun.,
April 1, 2000;
68(4):
2259 - 2267.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Clemons, A. Watson, A. Howell, J. Chang, C. Heyworth, B. Lord, N. Testa, T. M. Dexter, and G. Margison
Macrophage Inflammatory Protein 1{{alpha}} Attenuates the Toxic Effects of Temozolomide in Human Bone Marrow Granulocyte- Macrophage Colony-forming Cells
Clin. Cancer Res.,
March 1, 2000;
6(3):
966 - 970.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. E. J. Cotterell, C. R. Engwerda, and P. M. Kaye
Leishmania donovani infection of bone marrow stromal macrophages selectively enhances myelopoiesis, by a mechanism involving GM-CSF and TNF-alpha
Blood,
March 1, 2000;
95(5):
1642 - 1651.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. E. Broxmeyer, S. Cooper, G. Hangoc, J.-L. Gao, and P. M. Murphy
Dominant Myelopoietic Effector Functions Mediated by Chemokine Receptor CCR1
J. Exp. Med.,
June 21, 1999;
189(12):
1987 - 1992.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. E. Nicholls, G. Lucas, G. J. Graham, N. H. Russell, R. Mottram, A. D. Whetton, and A.-M. Buckle
Macrophage-Inflammatory Protein-1{alpha} Receptor Expression on Normal and Chronic Myeloid Leukemia CD34+ Cells
J. Immunol.,
May 15, 1999;
162(10):
6191 - 6199.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Dürig, N. G. Testa, and C. M. Heyworth
Distinct Biological Effects of Macrophage Inflammatory Protein-1{alpha} and Stroma-Derived Factor-1{alpha} on CD34+ Hemopoietic Cells
Stem Cells,
March 1, 1999;
17(2):
62 - 71.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. Reid, A. Ritchie, L. Boring, J. Gosling, S. Cooper, G. Hangoc, I. F. Charo, and H. E. Broxmeyer
Enhanced Myeloid Progenitor Cell Cycling and Apoptosis in Mice Lacking the Chemokine Receptor, CCR2
Blood,
March 1, 1999;
93(5):
1524 - 1533.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Durig, E. A. de Wynter, C. Kasper, M. A. Cross, J. Chang, N. G. Testa, and C. M. Heyworth
Expression of Macrophage Inflammatory Protein-1alpha Receptors in Human CD34+ Hematopoietic Cells and Their Modulation by Tumor Necrosis Factor-alpha and Interferon-gamma
Blood,
November 1, 1998;
92(9):
3073 - 3081.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.D. Cashman, C.J. Eaves, A.H. Sarris, and A.C. Eaves
MCP-1, not MIP-1alpha , Is the Endogenous Chemokine That Cooperates With TGF-beta to Inhibit the Cycling of Primitive Normal but not Leukemic (CML) Progenitors in Long-Term Human Marrow Cultures
Blood,
October 1, 1998;
92(7):
2338 - 2344.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Yanagihara, E. Komura, J. Nagafune, H. Watarai, and Y. Yamaguchi
EBI1/CCR7 Is a New Member of Dendritic Cell Chemokine Receptor That Is Up-Regulated upon Maturation
J. Immunol.,
September 15, 1998;
161(6):
3096 - 3102.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E.A. de Wynter, J. Durig, M.A. Cross, C.M. Heyworth, and N.G. Testa
Differential Response of CD34+ Cells Isolated from Cord Blood and Bone Marrow to MIP-1{alpha} and the Expression of MIP-1{alpha} Receptors on These Immature Cells
Stem Cells,
September 1, 1998;
16(5):
349 - 356.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. Ohta, T. Sakai, Y. Saga, S.-i. Aizawa, and M. Saito
Suppression of Hematopoietic Activity in Tenascin-C-Deficient Mice
Blood,
June 1, 1998;
91(11):
4074 - 4083.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. S. Haneline, H. E. Broxmeyer, S. Cooper, G. Hangoc, M. Carreau, M. Buchwald, and D. W. Clapp
Multiple Inhibitory Cytokines Induce Deregulated Progenitor Growth and Apoptosis in Hematopoietic Cells From Fac-/- Mice
Blood,
June 1, 1998;
91(11):
4092 - 4098.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B.-S. Youn, S. M. Zhang, H. E. Broxmeyer, S. Cooper, K. Antol, M. Fraser Jr, and B. S. Kwon
Characterization of CKbeta 8 and CKbeta 8-1: Two Alternatively Spliced Forms of Human beta -Chemokine, Chemoattractants for Neutrophils, Monocytes, and Lymphocytes, and Potent Agonists at CC Chemokine Receptor 1
Blood,
May 1, 1998;
91(9):
3118 - 3126.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. D. Krathwohl, R. Hromas, D. R. Brown, H. E. Broxmeyer, and K. H. Fife
Functional characterization of the C---C chemokine-like molecules encoded by molluscum contagiosum virus types 1 and 2
PNAS,
September 2, 1997;
94(18):
9875 - 9880.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Nagira, T. Imai, K. Hieshima, J. Kusuda, M. Ridanpaa, S. Takagi, M. Nishimura, M. Kakizaki, H. Nomiyama, and O. Yoshie
Molecular Cloning of a Novel Human CC Chemokine Secondary Lymphoid-Tissue Chemokine That Is a Potent Chemoattractant for Lymphocytes and Mapped to Chromosome 9p13
J. Biol. Chem.,
August 1, 1997;
272(31):
19518 - 19524.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. J. Rollins
Chemokines
Blood,
August 1, 1997;
90(3):
909 - 928.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-L. Gao, T. A. Wynn, Y. Chang, E. J. Lee, H. E. Broxmeyer, S. Cooper, H. L. Tiffany, H. Westphal, J. Kwon-Chung, and P. M. Murphy
Impaired Host Defense, Hematopoiesis, Granulomatous Inflammation and Type 1-Type 2 Cytokine Balance in Mice Lacking CC Chemokine Receptor 1
J. Exp. Med.,
June 2, 1997;
185(11):
1959 - 1968.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Yoshida, T. Imai, K. Hieshima, J. Kusuda, M. Baba, M. Kitaura, M. Nishimura, M. Kakizaki, H. Nomiyama, and O. Yoshie
Molecular Cloning of a Novel Human CC Chemokine EBI1-ligand Chemokine That Is a Specific Functional Ligand for EBI1, CCR7
J. Biol. Chem.,
May 23, 1997;
272(21):
13803 - 13809.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Hromas, P. W. Gray, D. Chantry, R. Godiska, M. Krathwohl, K. Fife, G. I. Bell, J. Takeda, S. Aronica, M. Gordon, et al.
Cloning and Characterization of Exodus, a Novel beta -Chemokine
Blood,
May 1, 1997;
89(9):
3315 - 3322.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Imai, T. Yoshida, M. Baba, M. Nishimura, M. Kakizaki, and O. Yoshie
Molecular Cloning of a Novel T Cell-directed CC Chemokine Expressed in Thymus by Signal Sequence Trap Using Epstein-Barr Virus Vector
J. Biol. Chem.,
August 30, 1996;
271(35):
21514 - 21521.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N Basara, S Stosic-Grujicic, D Sefer, Z Ivanovic, P Antunovic, and P Milenkovic
The inhibitory effect of human macrophage inflammatory protein-1 alpha (LD78) on acute myeloid leukemia cells in vitro
Stem Cells,
July 1, 1996;
14(4):
445 - 451.
[Abstract]
|
|
|
|
|
|
|
F. Cocchi, A. L. DeVico, A. Garzino-Demo, S. K. Arya, R. C. Gallo, and P. Lusso
Identification of RANTES, MIP-1alpha, and MIP-1beta as the Major HIV-Suppressive Factors Produced by CD8+ T Cells
Science,
December 15, 1995;
270(5243):
1811 - 1815.
[Abstract]
[PDF]
|
|
|
|
|
|
|
T. J. Daly, G. J. LaRosa, S. Dolich, T. E. Maione, S. Cooper, and H. E. Broxmeyer
High Activity Suppression of Myeloid Progenitor Proliferation by Chimeric Mutants of Interleukin 8 and Platelet Factor 4
J. Biol. Chem.,
October 6, 1995;
270(40):
23282 - 23292.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K Tashiro, H Tada, R Heilker, M Shirozu, T Nakano, and T Honjo
Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins
Science,
July 30, 1993;
261(5121):
600 - 603.
[Abstract]
[PDF]
|
|
|
|
|
