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Ultrastructural localization of a macrophage-restricted sialic acid binding
hemagglutinin, SER, in macrophage-hematopoietic cell clusters
PR Crocker, Z Werb, S Gordon and DF Bainton
Sir William Dunn School of Pathology, University of Oxford, UK.
Resident bone marrow macrophages in hematopoietic clusters have previously
been shown to express a novel lectin-like sheep erythrocyte receptor, SER,
which mediates binding of unopsonized sheep erythrocytes via recognition of
sialylated glycoconjugates and may interact with sialylated ligands on
murine bone marrow cells. In this study, the distribution of SER on
macrophages within hematopoietic clusters was localized by a monoclonal
antibody, SER-4, by immunofluorescence and immunoelectron microscopy. SER
was found to be diffusely localized at the contact zones between
macrophages and erythroblasts, whereas the receptor was highly concentrated
at the contacts between macrophages and developing myelomonocytic cells.
These data suggest that SER on resident bone marrow macrophages interacts
differentially with sialylated ligands on developing myeloid cells and that
this may influence their development.
Volume 76,
Issue 6,
pp. 1131-1138,
09/15/1990
Copyright © 1990 by The American Society of Hematology
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