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The t(1;14)(p34;q11) is nonrandom and restricted to T-cell acute
lymphoblastic leukemia: a Pediatric Oncology Group study
AJ Carroll, WM Crist, MP Link, MD Amylon, DJ Pullen, AH Ragab, GR Buchanan, RS Wimmer and TJ Vietti
University of Alabama, Birmingham.
We report the nonrandom occurrence, frequency, and degree of
immunophenotype association of the t(1;14)(p34;q11) in children with acute
lymphoblastic leukemia (ALL). This chromosomal abnormality occurred in
leukemia cells from 5 of 1,630 (0.3%) consecutive children with newly
diagnosed ALL who were entered on a single Pediatric Oncology Group
classification study (POG 8600) between January 1986 and February 1989. The
frequency of the t(1;14) was 3% (5 of 168 cases) in children with T-cell
ALL. All five cases had pseudodiploid karyotypes, and in 3 cases the
t(1;14) was accompanied by a deletion of the long arm of chromosome 6. This
translocation is of special interest because the breakpoint on chromosome
14 in band q11 corresponds to the assigned locus of the T-cell receptor
alpha/delta chain gene. All five of our patients and three cases reported
previously have had T-cell ALL. These findings, considered together,
suggest that this translocation is specific for T-cell ALL and that a gene
in the 1p34 region may play an important role in malignant transformation
of thymocytes.
Volume 76,
Issue 6,
pp. 1220-1224,
09/15/1990
Copyright © 1990 by The American Society of Hematology
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