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Stage-dependent effect of deferoxamine on growth of Plasmodium falciparum
in vitro
S Whitehead and TE Peto
Nuffield Department of Medicine, John Radcliffe Hospital, Headington,
Oxford, England.
Deferoxamine (DF) has antimalarial activity that can be demonstrated in
vitro and in vivo. This study is designed to examine the speed of onset and
stage dependency of growth inhibition by DF and to determine whether its
antimalarial activity is cytostatic or cytocidal. Growth inhibition was
assessed by suppression of hypoxanthine incorporation and differences in
morphologic appearance between treated and control parasites. Using
synchronized in vitro cultures of Plasmodium falciparum, growth inhibition
by DF was detected within a single parasite cycle. Ring and nonpigmented
trophozoite stages were sensitive to the inhibitory effect of DF but
cytostatic antimalarial activity was suggested by evidence of parasite
recovery in later cycles. However, profound growth inhibition, with no
evidence of subsequent recovery, occurred when pigmented trophozoites and
early schizonts were exposed to DF. At this stage in parasite development,
the activity of DF was cytocidal and furthermore, the critical period of
exposure may be as short as 6 hours. These observations suggest that iron
chelators may have a role in the treatment of clinical malaria.
Volume 76,
Issue 6,
pp. 1250-1255,
09/15/1990
Copyright © 1990 by The American Society of Hematology
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