|
|
 Previous Article | Table of Contents | Next Article 
Multiple myeloma: increased circulating lymphocytes carrying plasma
cell-associated antigens as an indicator of poor survival
P Omede, M Boccadoro, G Gallone, R Frieri, S Battaglio, V Redoglia and A Pileri
Dipartimento di Medicina ed Oncologia Sperimentale, University of Torino,
Italy.
In multiple myeloma (MM) an increase in circulating lymphocytes expressing
plasma cell-associated antigens (PCAA) has been described. Its prognostic
significance was evaluated in this study. The immunologic phenotype of
peripheral blood lymphocytes was analyzed with a panel of monoclonal
antibodies specific for B, T, natural killer lymphocytes, and PCAA (CD38,
PCA1) in 52 MM patients at diagnosis, remission, and during relapse, 18
monoclonal gammopathy of undetermined significance (MGUS), and 25 normal
controls. No significant phenotypic alteration was observed in MGUS. In MM,
the number of B lymphocytes was in the normal range at diagnosis and during
the subsequent phases. A CD4/CD8 ratio decrease, during relapse, was due to
both a CD4+ reduction and to an expansion of a subset of CD8+ activated
suppressor lymphocytes. CD38+ and PCA1+ lymphocytes at diagnosis were
significantly higher than in MGUS, and a further increase was observed
during relapse, suggesting a correlation between PCAA expression and
disease activity. The prognostic significance of increased PCAA was
confirmed by a survival analysis of 32 patients evaluated at diagnosis
using a CD38 cutoff of 0.45 x 10(9)/L positive lymphocytes. Median survival
for patients with high values was only 14 months, whereas it was not
reached at 32 months by those with low values (P less than .0007).
Volume 76,
Issue 7,
pp. 1375-1379,
10/01/1990
Copyright © 1990 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
G. S. Nowakowski, T. E. Witzig, D. Dingli, M. J. Tracz, M. A. Gertz, M. Q. Lacy, J. A. Lust, A. Dispenzieri, P. R. Greipp, R. A. Kyle, et al.
Circulating plasma cells detected by flow cytometry as a predictor of survival in 302 patients with newly diagnosed multiple myeloma
Blood,
October 1, 2005;
106(7):
2276 - 2279.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kumar, S. V. Rajkumar, R. A. Kyle, M. Q. Lacy, A. Dispenzieri, R. Fonseca, J. A. Lust, M. A. Gertz, P. R. Greipp, and T. E. Witzig
Prognostic Value of Circulating Plasma Cells in Monoclonal Gammopathy of Undetermined Significance
J. Clin. Oncol.,
August 20, 2005;
23(24):
5668 - 5674.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Ibrahim, M. Keating, K.-A. Do, S. O'Brien, Y. O. Huh, I. Jilani, S. Lerner, H. M. Kantarjian, and M. Albitar
CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia
Blood,
July 1, 2001;
98(1):
181 - 186.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
