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Release of tumor necrosis factor by human polymorphonuclear leukocytes
JY Djeu, D Serbousek and DK Blanchard
Department of Medical Microbiology and Immunology, University of South
Florida, College of Medicine, Tampa 33612.
Evidence is presented that human polymorphonuclear neutrophils (PMN) can be
induced to produce tumor necrosis factor (TNF). Other investigators have
previously reported that TNF has been induced from macrophages by bacteria
and, more recently, from natural killer cells by certain tumor cells. Our
laboratory has reported that the opportunistic fungi, Candida albicans, can
induce TNF, not only from human monocytes, but also from
Percoll-fractionated large granular lymphocytes. We now report that
incubation of PMN with C albicans for 3 hours was sufficient for detection
of TNF release, and peak induction was observed at 8 to 18 hours. This
release was inhibitable by actinomycin D, an inhibitor of RNA synthesis, as
well as by emetine and cycloheximide, which block protein synthesis. The
TNF produced by PMN was neutralized by specific monoclonal antibodies
against human TNF. These results represent an important finding that TNF
production is a normal response of PMN to stimulation by fungi such as C
albicans and suggest that the release of TNF may be related to autocrine
activation of PMN effector function to control Candida growth.
Volume 76,
Issue 7,
pp. 1405-1409,
10/01/1990
Copyright © 1990 by The American Society of Hematology
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