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Identification of novel B-lineage cells in human fetal bone marrow that
coexpress CD7 [see comments]
ER Grumayer, F Griesinger, DS Hummell, RD Brunning and JH Kersey
Department of Laboratory Medicine and Pathology, University of Minnesota,
Minneapolis 55455.
In the present study we used multiparameter flow cytometry and cell sorting
to evaluate fetal bone marrow, a rich source of cells early in lymphoid
development. We found CD7 to be expressed on a subset of CD19+ cells,
including some that had matured to cytoplasmic mu+ (pre-B) and surface mu+
(B) cells. In addition, a less mature CD7+19+ population was characterized
as mu- and CD34+/-. The CD7+19+ population was clearly distinct from the
mature T cells. The CD7+19+ cells were negative for nuclear TdT in contrast
to CD7-19+ cells, which frequently contained TdT. CD10, which is
coexpressed on the cell surface of more than 90% of CD19+ lymphocytes, was
detected in a minority of CD7+19+ lymphocytes. The CD7+19+34+ cell
population may be B-lineage committed, or may represent uncommitted
lymphoid precursors. The biologic role of the expression of CD7 on immature
and mature cells, including those of the B lineage, may indicate (1) the
presence of CD7+19+ lymphoid precursor cells and/or (2) an alternate
pathway of B-cell development, in which cells coexpress CD7 with other
B-lineage markers.
Volume 77,
Issue 1,
pp. 64-68,
01/01/1991
Copyright © 1991 by The American Society of Hematology
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