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Leukemia inhibitory factor can potentiate murine megakaryocyte production
in vitro
D Metcalf, D Hilton and NA Nicola
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne
Hospital, Victoria, Australia.
Receptors for murine leukemia inhibitory factor (LIF) were demonstrated on
immature and mature murine megakaryocytes. LIF alone had no effects in
culture on the survival or proliferation of normal murine megakaryocytes or
their precursors. However, combination of LIF with
multipotential-colony-stimulating factor (Multi-CSF) (interleukin-3)
enhanced the megakaryocyte colony formation able to be stimulated by
Multi-CSF; the enhancement involved all types of megakaryocyte colony and
resulted in the formation of increased numbers of megakaryocytes. These
observations provide a possible basis for the observation that, when LIF is
injected in vivo, elevations are observed in megakaryocyte numbers and
platelet levels.
Volume 77,
Issue 10,
pp. 2150-2153,
05/15/1991
Copyright © 1991 by The American Society of Hematology
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