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Granulocyte colony-stimulating factor in cerebrospinal fluid from patients
with meningitis
K Shimoda, S Okamura, F Omori, Y Mizuno, T Hara, T Aoki, K Ueda and Y Niho
First Department of Internal Medicine, Kyushu University, Fukuoka, Japan.
Granulocyte colony-stimulating factor (G-CSF) in the cerebrospinal fluid
from patients with meningitis was measured by our modified enzyme- linked
immunosorbent assay for G-CSF. The minimal detection level was 20 pg/mL
G-CSF. In patients with bacterial meningitis, the G-CSF levels in the
cerebrospinal fluid were extremely elevated, showing a mean value of
approximately 1,500 pg/mL. On the other hand, G-CSF levels in the
cerebrospinal fluid from 67% patients with aseptic meningitis were
moderately increased, showing a mean value of about 80 pg/mL, whereas G-
CSF levels in 33% samples remained undetectable. The G-CSF levels and
neutrophil counts in the cerebrospinal fluid were proven to be related by
Spearman's rank correlation coefficient analysis (r = .724). These
elevations of G-CSF levels at inflammation sites associated with bacterial
meningitis may indicate that G-CSF plays an important role in the combat of
bacterial infections.
Volume 77,
Issue 10,
pp. 2214-2217,
05/15/1991
Copyright © 1991 by The American Society of Hematology
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