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A soluble factor released by CD8+CD57+ lymphocytes from bone marrow
transplanted patients inhibits cell-mediated cytolysis
B Autran, V Leblond, B Sadat-Sowti, E Lefranc, P Got, L Sutton, JL Binet and P Debre
Laboratoire d'Immunologie Cellulaire et Tissulaire, UA CNRS 186, Paris,
France.
We report a new inhibitory activity of CD8+CD57+ peripheral blood
lymphocytes from allo-bone marrow transplant patients. Positively selected
CD8+CD57+ lymphocytes act as potent inhibitors of allospecific cytolytic T
lymphocyte and lymphokine activated killer cell cytolytic activities. These
suppressor cells are mature T cells expressing the CD2, 5, 7, CD3-TcR alpha
beta complex, and lack natural killer cell markers as well as cytolytic
function. Their inhibitory activity on both cytolytic processes and T-cell
proliferation is mediated by a non- antigen-specific soluble factor
released by CD8+CD57+ cells in culture supernatants. Preliminary
characterization suggests that the CD8+CD57+ cells' inhibitory activity is
mediated by a low molecular weight, glycosylated factor as indicated by its
less than 1S coefficient of sedimentation and its binding to concanavalin A
lectin.
Volume 77,
Issue 10,
pp. 2237-2241,
05/15/1991
Copyright © 1991 by The American Society of Hematology
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