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Human monocytes bind to two cytokine-induced adhesive ligands on cultured
human endothelial cells: endothelial-leukocyte adhesion molecule-1 and
vascular cell adhesion molecule-1
T Carlos, N Kovach, B Schwartz, M Rosa, B Newman, E Wayner, C Benjamin, L Osborn, R Lobb and J Harlan
Department of Medicine (Hematology), University of Washington, Seattle.
Vascular cell adhesion molecule-1 (VCAM-1) and endothelial-leukocyte
adhesion molecule-1 (ELAM-1) are adhesive proteins induced on endothelium
by cytokines. We examined the contribution of these adhesive proteins to
human peripheral blood monocyte adherence to endothelium using transfected
Chinese hamster ovary (CHO) cells stably expressing these proteins and
monoclonal antibodies (MoAbs) to ELAM-1, VCAM-1, or CD49d/CD29 (VLA-4), the
leukocyte receptor for VCAM-1. Monocytes bound to CHO cells transfected
with cDNA of ELAM-1 or VCAM-1. Binding to ELAM-1 was inhibited by MoAb to
ELAM-1 and binding to VCAM-1 was inhibited by MoAb to VCAM-1 or the
alpha-chain of very late activation antigen-4 (VLA-4) (CD49d). Additive
inhibition of adherence to unstimulated human umbilical vein endothelium
(HUVE) was observed when monocytes were pretreated with both MoAb to CD49d
and MoAb to CD18, the common beta-chain of the leukocyte beta 2 integrin
receptors. Adherence of monocytes to HUVE stimulated by recombinant human
tumor necrosis factor-alpha was not reduced by MoAbs to CD18, CD49d, or
ELAM- 1 when used singly, but combinations of these MoAbs produced
significant inhibition. We conclude that multiple receptor-ligand systems
are involved in monocyte adherence to endothelium.
Volume 77,
Issue 10,
pp. 2266-2271,
05/15/1991
Copyright © 1991 by The American Society of Hematology
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