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Developmental hematopoiesis in normal human fetal blood
F Forestier, F Daffos, N Catherine, M Renard and JP Andreux
Service de Medicine et de Biologie Foetales, Institut de Puericulture de
Paris, France.
Using an easy and safe procedure for fetal blood sampling in utero, we
studied 3,415 fetuses for prenatal diagnosis. Retrospectively, 2,860 normal
blood samples, performed from the 18th week of gestation to the end of
pregnancy, were selected. Differentials were evaluated in 732 cases.
Burst-forming unit erythroid (BFU-E) and erythropoietin (Epo) were measured
in 27 and 163 cases, respectively. Total nucleated cell and platelet counts
did not change from the 18th to the 30th week of gestation. The lymphocytes
represented the main population and the decrease of normoblastic cells made
up for the increase in neutrophils. The increase of red blood cells and
hemoglobin was substantial during the studied period. At mid trimester
threefold more BFU-E were obtained than at birth. Epo levels remained
stable throughout the pregnancy and no correlation was found between Epo
and gestational age. These normal values of fetal erythropoiesis will
improve our knowledge of physiology and provide a better insight into
developmental hematopoiesis.
Volume 77,
Issue 11,
pp. 2360-2363,
06/01/1991
Copyright © 1991 by The American Society of Hematology
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