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Expression of interleukin-6 and interleukin-6 receptor in Hodgkin's disease
M Jucker, H Abts, W Li, R Schindler, H Merz, A Gunther, C von Kalle, M Schaadt, T Diamantstein and AC Feller
I. Medizinische Klinik, Universitat Koln, Germany.
Interleukin-6 (IL-6) is a multipotent lymphokine that can mediate
differentiation of B cells into Ig-secreting cells, stimulate the growth of
plasmacytomas, hybridomas, and T cells, and induce acute- phase proteins in
liver cells. It has been suggested that IL-6 is involved in the
pathogenesis of several diseases by autocrine or paracrine pathways. To
examine whether IL-6 is possibly involved in the pathophysiology of
Hodgkin's disease (HD), we analyzed the expression of IL-6 and IL-6
receptor mRNA and protein in cell lines and primary specimens from patients
with HD. IL-6-specific transcripts were detected in three of six HD-derived
cell lines by Northern blot analysis. In the culture supernatants of four
HD-derived cell lines, IL- 6 was detected by radioimmunoassay. Biologic
activity of IL-6 was confirmed by proliferation of an IL-6-dependent cell
line. In situ hybridization experiments showed IL-6-specific transcripts in
Hodgkin (H) and Reed-Sternberg (RS) cells in primary tissues of two
patients. In addition, mRNAs specific for the IL-6 receptor were detected
in five HD-derived cell lines. Immunostaining experiments showed expression
of IL-6 receptor molecules on H and RS cells in 8 of 16 cases with HD.
Thus, our data suggest that IL-6 might be involved in the pathophysiology
of HD.
Volume 77,
Issue 11,
pp. 2413-2418,
06/01/1991
Copyright © 1991 by The American Society of Hematology
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