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Autologous bone marrow transplantation in 69 patients with a history of
low-grade B-cell non-Hodgkin's lymphoma
AS Freedman, J Ritz, D Neuberg, KC Anderson, SN Rabinowe, P Mauch, T Takvorian, R Soiffer, K Blake and B Yeap
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA
02115.
Sixty-nine patients with a history of low-grade B-cell non-Hodgkin's
lymphoma (NHL) in sensitive relapse or incomplete first remission underwent
high-dose chemoradiotherapy and anti-B-cell monoclonal antibody
(MoAb)-treated autologous bone marrow transplantation (ABMT). At ABMT, 51
patients had low-grade histology and 18 patients had a history of low-grade
NHL that had undergone histologic transformation to a higher-grade NHL.
Before ABMT, only 20 of the 51 low-grade patients and 10 of the 18 patients
with transformed histologies were in complete remission. Moreover, at the
time of marrow harvest, 24 of the low-grade and eight of the transformed
histology patients had histologic evidence of lymphoma cells infiltrating
the marrow. Following high-dose therapy, only one acute, in-hospital death
was observed. There was no significant difference in the disease-free
survival (DFS) between patients with low-grade and patients with
transformed histologies. Among patients with low-grade NHL, the patients in
complete remission before ABMT experienced significantly longer DFS than
those in partial remission (P less than .05). This preliminary study
suggests that some patients with relapsed low-grade NHL may experience
prolonged DFS following high-dose ablative therapy.
Volume 77,
Issue 11,
pp. 2524-2529,
06/01/1991
Copyright © 1991 by The American Society of Hematology
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