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Lectin-like cell adhesion molecule 1 mediates leukocyte rolling in
mesenteric venules in vivo
K Ley, P Gaehtgens, C Fennie, MS Singer, LA Lasky and SD Rosen
Department of Physiology, Freie Universitat Berlin, Germany.
During the inflammatory response, granulocytes and other leukocytes adhere
to and emigrate from small venules. Before firm attachment, leukocytes are
observed rolling slowly along the endothelium in venules of most tissues
accessible to intravital microscopy. The molecular mechanism underlying
this early type of leukocyte-endothelial interaction is unknown. Leukocyte
rolling was investigated in venules (diameter, 40 microns) of the exposed
rat mesentery. Micro-infusion of a recombinant soluble chimera (LEC-IgG) of
the murine homing receptor lectin-like cell adhesion molecule 1 (LEC-CAM 1;
gp90MEL) into individual venules reduced the number of rolling leukocytes
by 89% +/- 2% (mean +/- SEM, n = 20 venules), while a similar CD4 chimera
(CD4- IgG) had no effect (inhibition 14% +/- 7%, n = 25). Rolling was also
greatly reduced by a polyclonal serum against LEC-CAM 1 (inhibition 84% +/-
3%, n = 35); preimmune serum was ineffective (11% +/- 13% inhibition, n =
28). These findings indicate that LEC-CAM 1 mediates the adhesive
interaction underlying leukocyte rolling and thus may play an important
role in inflammation and in pathologic conditions involving leukocytes.
Volume 77,
Issue 12,
pp. 2553-2555,
06/15/1991
Copyright © 1991 by The American Society of Hematology
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