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Translocation (9;22) is associated with extremely poor prognosis in
intensively treated children with acute lymphoblastic leukemia
JA Fletcher, EA Lynch, VM Kimball, M Donnelly, R Tantravahi and SE Sallan
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.
The prognostic implications of t(9;22)(q34;q11) were assessed at a median
follow-up of 3.5 years in 434 children receiving intensive treatment for
acute lymphoblastic leukemia (ALL). Four-year event-free and overall
survivals were 81% and 88%, respectively, in 419 children lacking t(9;22),
but were 0% and 20%, respectively, in 15 children with t(9;22) (P less than
.001). Poor outcome for children with t(9;22)- positive ALL was
particularly notable because we have reported improved survival in other
historically poor prognosis ALL cytogenetic categories when treated with
similarly intensive therapy. We recommend that very intensive treatment
approaches, including bone marrow transplantation in first remission, be
considered for all children with t(9;22)-positive ALL.
Volume 77,
Issue 3,
pp. 435-439,
02/01/1991
Copyright © 1991 by The American Society of Hematology
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