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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Rolovic, Z. Articles by Pavlovic-Kentera, V. Search for Related Content PubMed PubMed Citation Articles by Rolovic, Z. Articles by Pavlovic-Kentera, V. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Abnormal megakaryocytopoiesis in the Belgrade laboratory rat Z Rolovic, N Basara, N Stojanovic, N Suvajdzic and V Pavlovic-Kentera Medical Faculty of Belgrade University, Yugoslavia. The Belgrade laboratory (b/b) rat has a hereditary hypochromic microcytic anemia because of defective transmembrane iron transport into erythroblasts. The present study was prompted by our previous work in which we showed that the b/b rat has hypomegakaryocytic thrombocytopenia associated with increased megakaryocyte size. To define the basic mechanism underlying this abnormality in the b/b rat we have studied both megakaryocytopoiesis and granulopoiesis in anemic b/b rats, chronically transfused b/b rats, iron-treated b/b rats, and controls. We have found decreased concentrations of megakaryocyte and granulocyte progenitors in the marrow of b/b rats. Full correction of the severe anemia by chronic transfusion resulted in normalization of megakaryocyte progenitors, small acetylcholinesterase positive cells, megakaryocyte size, and platelet counts, along with granulocyte progenitors. In contrast, the partial correction of anemia obtained by iron treatment resulted in improvement, but not normalization, of these parameters. These findings indicate that abnormal megakaryocytopoiesis in the b/b rat can be best interpreted as a consequence of hypoxia because of the severe anemia. Because we have recently shown that the number of erythroid progenitors in b/b rats is also low, we propose that abnormal megakaryocytopoiesis in this animal is a reflection of an acquired stem cell disorder induced by the prolonged hypoxia resulting from the severe anemia. Volume 77, Issue 3, pp. 456-460, 02/01/1991 Copyright © 1991 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. D. Potter, S. G. Shinpock, R. A. Popp, D. M. Popp, V. Godfrey, D. A. Carpenter, A. Bernstein, D. K. Johnson, and E. M. Rinchik Mutations in the Murine Fitness 1 Gene Result in Defective Hematopoiesis Blood, September 1, 1997; 90(5): 1850 - 1857. [Abstract] [Full Text] [PDF]

	Copyright © 1991 by American Society of Hematology         Online ISSN: 1528-0020