|
|
 Previous Article | Table of Contents | Next Article 
Expression of thrombomodulin by smooth muscle cells in culture: different
effects of tumor necrosis factor and cyclic adenosine monophosphate on
thrombomodulin expression by endothelial cells and smooth muscle cells in
culture
GA Soff, RW Jackman and RD Rosenberg
Department of Medicine, Beth Israel Hospital, Boston, MA.
Thrombomodulin (TM), a critical component of the protein C anticoagulant
pathway, has previously been localized to endothelial cells (EC), but not
smooth muscle cells (SMC) of the blood vessel wall. We demonstrate that
cultured rat, bovine, as well as human SMC, but not blood vessel wall
smooth muscle tissue, possess significant functional levels of TM and TM
mRNA. Cyclic adenosine monophosphate stimulates TM expression in cultured
SMC, but not EC, while tumor necrosis factor suppresses TM expression in EC
but not cultured SMC. We postulate that following acute or chronic EC
injury, luminal SMC can express TM, and are therefore able to protect the
damaged blood vessel from thrombosis.
Volume 77,
Issue 3,
pp. 515-518,
02/01/1991
Copyright © 1991 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
K. Rabausch, E. Bretschneider, M. Sarbia, J. Meyer-Kirchrath, P. Censarek, R. Pape, J. W. Fischer, K. Schror, and A.-A. Weber
Regulation of Thrombomodulin Expression in Human Vascular Smooth Muscle Cells by COX-2-Derived Prostaglandins
Circ. Res.,
January 7, 2005;
96(1):
e1 - e6.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Sperry, C. B. Deming, C. Bian, P. L. Walinsky, D. A. Kass, F. D. Kolodgie, R. Virmani, A. Y. Kim, and J. J. Rade
Wall Tension Is a Potent Negative Regulator of In Vivo Thrombomodulin Expression
Circ. Res.,
January 10, 2003;
92(1):
41 - 47.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Le Flem, V. Picard, J. Emmerich, S. Gandrille, J.-N. Fiessinger, M. Aiach, and M. Alhenc-Gelas
Mutations in Promoter Region of Thrombomodulin and Venous Thromboembolic Disease
Arterioscler. Thromb. Vasc. Biol.,
April 1, 1999;
19(4):
1098 - 1104.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Healy, W. W. Hancock, P. D. Christie, H. B. Rayburn, and R. D. Rosenberg
Intravascular Coagulation Activation in a Murine Model of Thrombomodulin Deficiency: Effects of Lesion Size, Age, and Hypoxia on Fibrin Deposition
Blood,
December 1, 1998;
92(11):
4188 - 4197.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. M. Conway, S. Pollefeyt, D. Collen, and M. Steiner-Mosonyi
The Amino Terminal Lectin-Like Domain of Thrombomodulin Is Required for Constitutive Endocytosis
Blood,
January 15, 1997;
89(2):
652 - 661.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. L. Chaikof, R. Caban, C.-N. Yan, G. N. Rao, and M. S. Runge
Growth-related Responses in Arterial Smooth Muscle Cells Are Arrested by Thrombin Receptor Antisense Sequences
J. Biol. Chem.,
March 31, 1995;
270(13):
7431 - 7436.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
