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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hamilton, J. A. Articles by Cocks, B. G. Search for Related Content PubMed PubMed Citation Articles by Hamilton, J. A. Articles by Cocks, B. G. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Activation and proliferation signals in murine macrophages. Biochemical signals controlling the regulation of macrophage urokinase-type plasminogen activator activity by colony-stimulating factors and other agents JA Hamilton, G Vairo, KR Knight and BG Cocks Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Parkville, Australia. Purified hematopoietic growth factors such as colony-stimulating factor- 1 (CSF-1) or macrophage CSF, granulocyte-macrophage CSF, and interleukin-3 or multi-CSF, stimulate the urokinase-type plasminogen activator (u-PA) activity of murine bone marrow-derived macrophages (BMM) and resident peritoneal macrophages. Granulocyte-CSF was inactive. The increases in BMM u-PA activity were inhibited by the glucocorticoid dexamethasone, and by agents that raise intracellular cyclic adenosine monophosphate levels, including prostaglandin E2 and cholera toxin. These changes in u-PA activity were paralleled by corresponding changes in u-PA mRNA levels. Evidence was obtained for protein kinase C and phospholipase C-mediated stimulation of BMM u-PA activity and mRNA levels; however, no evidence was found for an involvement of Na+/H+ exchange or Na+, K(+)-ATPase activity, Ca2+ fluxes, or pertussis toxin-sensitive G proteins. Several findings point to a dissociation between macrophage u-PA expression and DNA synthesis. Volume 77, Issue 3, pp. 616-627, 02/01/1991 Copyright © 1991 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. Lardot, M. Delos, and D. Lison Upregulation of urokinase in alveolar macrophages and lung tissue in response to silica particles Am J Physiol Lung Cell Mol Physiol, June 1, 1998; 274(6): L1040 - L1048. [Abstract] [Full Text] [PDF] H.-Y. Hsu, D. P. Hajjar, K. M. F. Khan, and D. J. Falcone Ligand Binding to Macrophage Scavenger Receptor-A Induces Urokinase-type Plasminogen Activator Expression by a Protein Kinase-dependent Signaling Pathway J. Biol. Chem., January 9, 1998; 273(2): 1240 - 1246. [Abstract] [Full Text] [PDF] A. E. Reifel-Miller, D. M. Conarty, K. M. Valasek, P. W. Iversen, D. J. Burns, and K. A. Birch Protein Kinase C Isozymes Differentially Regulate Promoters Containing PEA-3/12-O-Tetradecanoylphorbol-13-acetate Response Element Motifs J. Biol. Chem., August 30, 1996; 271(35): 21666 - 21671. [Abstract] [Full Text] [PDF] Y. Shoenfeld, M. Blank, and P. Fishman Antiphospholipid syndrome: from the laboratory bench to the patients' bedside Lupus, July 1, 1994; 4(1_suppl): S33 - S36. [PDF]

	Copyright © 1991 by American Society of Hematology         Online ISSN: 1528-0020