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Macrophage colony-stimulating factor (CSF-1) gene expression in human T-
lymphocyte clones
MM Hallet, V Praloran, H Vie, MA Peyrat, G Wong, J Witek-Giannotti, JP Soulillou and JF Moreau
INSERM U.211, Faculte de Medecine, Laboratoire d'Hematologie, Centre
Hospitalier Regional, Nantes, France.
Macrophage colony stimulating factor (CSF-1) is one of several cytokines
that control the differentiation, survival, and proliferation of monocytes
and macrophages. A set of 11 human T-cell clones, chosen for their
phenotypic diversity, were tested for their ability to express CSF-1 mRNA.
After 5 hours of stimulation with phorbol myristate acetate (PMA) + calcium
ionophore (Cal), all T-cell clones expressed a major 4-kb transcript, a
less abundant 2-kb transcript, and several other minor species. This
pattern of expression is typical for CSF-1 mRNAs. Furthermore, of the two
alloreactive T-cell clones analyzed, only one showed a definitive message
for CSF-1 on specific antigenic stimulation, but with delayed kinetics and
less efficiency. Both conditions of stimulation induced the release of
CSF-1 protein by T cells in the culture medium. Together, these findings
demonstrate for the first time that normal T cells are able to produce
CSF-1, previous reports being limited to two cases of tumoral cells of the
T-cell lineage.
Volume 77,
Issue 4,
pp. 780-786,
02/15/1991
Copyright © 1991 by The American Society of Hematology
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