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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lanotte, M. Articles by Berger, R. Search for Related Content PubMed PubMed Citation Articles by Lanotte, M. Articles by Berger, R. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3) M Lanotte, V Martin-Thouvenin, S Najman, P Balerini, F Valensi and R Berger INSERM U-301, SDI No 15954.1 CNRS, Centre Hayem, Paris, France. Acute promyelocytic leukemia (APL) is a well-defined entity among acute leukemia, cytogenetically characterized by a t(15;17) (q22;q11-12) translocation. In vitro and in vivo studies suggest that all-trans retinoic acid (RA) treatment restores cell maturation. We have isolated the first permanent cell line with t(15;17), derived from the marrow of a patient with APL in relapse. The establishment of the cell line, its morphologic, karyotypic, and immunohistochemical features are reported. RA induced cell line maturation. Cells strongly expressed myeloid markers, but also some T-cell markers. Additional karyotypic abnormalities, a 12p rearrangement and the possible presence of a homogeneous staining region (HSR) on 19q+ are discussed both in relation to T-cell (CD2, CD4) and monocyte (CD9) markers, and to the acquired cell growth autonomy. The cell line represents a remarkable tool for biomolecular studies. Volume 77, Issue 5, pp. 1080-1086, 03/01/1991 Copyright © 1991 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. K. Brouwer, J. Schimmel, J. C.A.G. Wiegant, A. C.O. Vertegaal, H. J. Tanke, and R. W. Dirks Telomeric DNA Mediates De Novo PML Body Formation Mol. Biol. Cell, November 15, 2009; 20(22): 4804 - 4815. [Abstract] [Full Text] [PDF] F. Lautenschlager, S. Paschke, S. Schinkinger, A. Bruel, M. Beil, and J. Guck The regulatory role of cell mechanics for migration of differentiating myeloid cells PNAS, September 15, 2009; 106(37): 15696 - 15701. [Abstract] [Full Text] [PDF] F. Pendino, E. Nguyen, I. Jonassen, B. Dysvik, A. Azouz, M. Lanotte, E. Segal-Bendirdjian, and J. R. Lillehaug Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis Blood, April 2, 2009; 113(14): 3172 - 3181. 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