|
|
 Previous Article | Table of Contents | Next Article 
Mutations of the p53 gene in lymphoid leukemia
K Sugimoto, H Toyoshima, R Sakai, K Miyagawa, K Hagiwara, H Hirai, F Ishikawa and F Takaku
Third Department of Internal Medicine, Faculty of Medicine, University of
Tokyo, Japan.
p53 is currently considered to be a tumor suppressor gene product, and its
alterations are suggested to be involved in several human malignancies.
Here we show evidence of the possible involvement of p53 gene mutations in
lymphoid leukemias studied by reverse transcriptase- polymerase chain
reaction, single strand conformation polymorphism analysis, and nucleotide
sequencing. Fourteen patients with various leukemias were examined and two
with acute lymphoblastic leukemia and one with Waldenstrom's
macroglobulinemia were identified to have mutations in the coding region of
the p53 gene. These mutations included point mutation, triplet deletion,
and single nucleotide insertion. Furthermore, expression of the wild-type
p53 mRNA was not detected in the samples from these three patients. In one
of them, chromosome 17p was deleted, suggesting the absence of the
nonmutated p53 gene, whereas in the other two patients, chromosome 17p
seemed to be intact by cytogenetic analysis. Our results suggest that
alterations of the p53 gene may have a role in the genesis of some
leukemias.
Volume 77,
Issue 6,
pp. 1153-1156,
03/15/1991
Copyright © 1991 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
F. Ide, H. Oda, Y. Nakatsuru, K. Kusama, H. Sakashita, K. Tanaka, and T. Ishikawa
Xeroderma pigmentosum group A gene action as a protection factor against 4-nitroquinoline 1-oxide-induced tongue carcinogenesis
Carcinogenesis,
April 1, 2001;
22(4):
567 - 572.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Maki, K. Mitani, T. Yamagata, M. Kurokawa, Y. Kanda, Y. Yazaki, and H. Hirai
Transcriptional Inhibition of p53 by the MLL/MEN Chimeric Protein Found in Myeloid Leukemia
Blood,
May 15, 1999;
93(10):
3216 - 3224.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Faderl, H. M. Kantarjian, M. Talpaz, and Z. Estrov
Clinical Significance of Cytogenetic Abnormalities in Adult Acute Lymphoblastic Leukemia
Blood,
June 1, 1998;
91(11):
3995 - 4019.
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Honda, H. Oda, T. Suzuki, T. Takahashi, O. N. Witte, K. Ozawa, T. Ishikawa, Y. Yazaki, and H. Hirai
Development of Acute Lymphoblastic Leukemia and Myeloproliferative Disorder in Transgenic Mice Expressing p210bcr/abl: A Novel Transgenic Model for Human Ph1-Positive Leukemias
Blood,
March 15, 1998;
91(6):
2067 - 2075.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
