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Interleukin-5 is a human basophilopoietin: induction of histamine content
and basophilic differentiation of HL-60 cells and of peripheral blood
basophil-eosinophil progenitors
JA Denburg, JE Silver and JS Abrams
Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Cytokine-induced differentiation of basophils may contribute to various
inflammatory processes. We examined the effects of recombinant human
interleukin-5 (IL-5) and other human cytokines in vitro on myeloid colony
formation in methylcellulose and on alkaline passaged HL-60 basophilic cell
differentiation. Myeloid colonies (CFU-C) at day 14, formed in the presence
of either IL-3, IL-5, granulocyte-macrophage colony-stimulating factor
(GM-CSF), or G-CSF included peripheral blood- derived progenitors of the
eosinophil/basophil lineage. IL-5 stimulated a greater proportion of
basophil-containing, histamine-positive, eosinophil-type colonies compared
with GM-CSF, IL-3, or G-CSF. IL-5 also stimulated dose-dependent increases
in histamine content of alkaline-passaged, butyrate cotreated HL-60 cells.
The concentration of IL-5 required for half-maximal induction of HL-60
histamine content was similar within twofold to that needed for
half-maximal stimulation of the multifactor dependent TF-1 erythroleukemic
cell line. Neutralizing rat monoclonal antibodies to human IL-5 were
developed and used to demonstrate that each of these IL-5 bioactivities
could be specifically blocked. We conclude that in addition to its
previously described eosinophil differentiation activity, IL-5 may be
considered a basophilopoietin.
Volume 77,
Issue 7,
pp. 1462-1468,
04/01/1991
Copyright © 1991 by The American Society of Hematology
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