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Epstein-Barr virus in benign lymph node biopsies from individuals infected
with the human immunodeficiency virus is associated with concurrent or
subsequent development of non-Hodgkin's lymphoma
D Shibata, LM Weiss, BN Nathwani, RK Brynes and AM Levine
Department of Pathology, Los Angeles County-University of Southern
California Medical Center.
Individuals infected with the human immunodeficiency virus (HIV) have an
increased incidence of high-grade B-cell lymphoma. In many instances, these
lymphomas contain Epstein-Barr viral (EBV) genomes. To investigate the role
of EBV in development of HIV-related lymphoma, benign fixed lymph node
biopsies from normal individuals and HIV- infected individuals with
persistent generalized lymphadenopathy (PGL) were analyzed for EBV
sequences by polymerase chain reaction and in situ DNA hybridization
techniques. EBV DNA was not detected in any of 16 benign lymph node
biopsies from normal individuals, but could be detected from 13 of 35 PGL
biopsies. The EBV-infected cells were present in both follicular and
interfollicular areas and in both small and large lymphoid cells. The
presence of detectable amounts of EBV DNA in the 13 PGL biopsies was
associated with an increased incidence of concurrent lymphoma at another
site (n = 3) or development of lymphoma in time (n = 2). In contrast, only
1 of 22 individuals with EBV- negative PGL biopsies developed lymphoma in
time (P less than .05). EBV was detected in all five lymphomas in which
tissue was available for subsequent analysis, including the lymphoma that
developed in the individual without EBV in his previous PGL biopsy. These
findings support the hypothesis that EBV plays a role in development of
some HIV- related lymphomas. Detectable EBV lymphoproliferations occur in a
few PGL biopsies and are associated with a significant risk of EBV DNA-
positive non-Hodgkin's lymphoma.
Volume 77,
Issue 7,
pp. 1527-1533,
04/01/1991
Copyright © 1991 by The American Society of Hematology
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