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Two distinct loci on the short arm of chromosome 16 are involved in myeloid leukemia

JW Wessels, P Mollevanger, JG Dauwerse, FH Cluitmans, MH Breuning and GC Beverstock

Department of Human Genetics, State University Hospital, Leiden, The Netherlands.

We report a case of acute nonlymphocytic leukemia (ANLL) M5 with the characteristic t(8;16)(p11;p13). The breakpoint in the short arm was regionally localized using nonradioactive in situ hybridization with a series of cosmids of chromosome 16. The results show that a difference exists between the breakpoint in chromosome 16(p13) in this t(8;16) and the breakpoint involved in the short arm in the characteristic inversion 16 (p13;q22)) that occurs in ANLL M4eo. Two different loci appear to be involved in these chromosomal rearrangements.

Volume 77, Issue 7, pp. 1555-1559, 04/01/1991
Copyright © 1991 by The American Society of Hematology


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