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Immunologic correlates of spontaneous lymphocyte proliferation in human
T-lymphotropic virus infection
HE Prince, H Lee, ER Jensen, P Swanson, D Weber, L Fitzpatrick, M Doyle and S Kleinman
American Red Cross Blood Services, Los Angeles, CA 90006.
Previously we showed that mononuclear cells from about half of human T-
lymphotropic virus (HTLV)-seropositive persons exhibit spontaneous
proliferation in vitro. We sought to determine if proliferation was
associated with other immunologic changes characteristic of HTLV infection.
The parameters assessed were (1) percentages of lymphocytes expressing CD4
and/or CD25 (interleukin-2 receptor), (2) serum levels of soluble CD25, (3)
serostatus for other viruses, (4) anti-HTLV antibody levels, and (5) HTLV
type determined by polymerase chain reaction or serologic reactivity with
type-specific peptides. The proliferation+ HTLV (PROL+) group,
proliferation HTLV (PROL-) group, and control group showed similar
percentages of CD4+, CD25+, and CD4+CD25+ lymphocytes; serum levels of
soluble CD25 were also similar. Antibodies to cytomegalovirus, hepatitis B
core, and hepatitis C were present in similar proportions of PROL+ and
PROL+ groups. However, a significant association was found between
spontaneous proliferation and anti-HTLV antibody levels; sera from 67% of
PROL+ persons, but only 18% of PROL- persons, required dilution to yield
absorbance values within the linear range of the anti-HTLV antibody assay.
In the PROL+ group, persons whose sera required the most dilution had
proliferative responses significantly higher than those whose sera required
no dilution. The PROL+ and PROL groups were similar with regard to the
relative distribution of HTLV-I and HTLV-II infection. These findings
indicate that HTLV-related spontaneous lymphocyte proliferation is related
to levels of circulating anti-HTLV antibodies, and characterizes both
HTLV-I and HTLV-II infection.
Volume 78,
Issue 1,
pp. 169-174,
07/01/1991
Copyright © 1991 by The American Society of Hematology
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