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Gene rearrangement in B- and T-lymphoproliferative disease detected by the
polymerase chain reaction [see comments]
KJ Trainor, MJ Brisco, JH Wan, S Neoh, S Grist and AA Morley
Department of Haematology, Flinders Medical Centre, Bedford Park, South
Australia.
Gene rearrangement and monoclonality have been detected in normal cells and
in lymphoproliferative disease by using the polymerase chain reaction and
primers for the V and J regions of the Ig heavy chain gene or T-cell
receptor gamma-chain gene. Using the Ig primers monoclonality was detected
in 20 of 20 normal B-lymphocyte clones and in 39 of 52 cases of various
types of B-lymphoproliferative disease, but not in 11 cases of
T-lymphoproliferative disease. Using the T-cell receptor primers,
monoclonality was detected in 186 of 192 normal T-lymphocyte clones, in 11
of 11 cases of T-lymphoproliferative disease, in 9 of 12 cases of B-acute
lymphocytic leukemia, and in 1 of 21 cases of B-non- Hodgkin's lymphoma,
but not in nine cases of B-chronic lymphocytic leukemia nor in 10 cases of
myeloma. Monoclonality was detected in material obtained by lymph node
aspiration in four of six additional cases of non-Hodgkin's lymphoma. It
was not detected in 10 cases of acute myeloid leukemia nor in four cases of
reactive lymphadenopathy. Detection of gene rearrangement by the polymerase
chain reaction has a number of advantages over Southern blotting and is
likely to become the initial diagnostic technique of choice to detect
monoclonality.
Volume 78,
Issue 1,
pp. 192-196,
07/01/1991
Copyright © 1991 by The American Society of Hematology
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