|
|
 Previous Article | Table of Contents | Next Article 
Increased antiplatelet T helper lymphocyte reactivity in patients with
autoimmune thrombocytopenia
JW Semple and J Freedman
Department of Immunohematology, St Michael's Hospital, Toronto, Ontario,
Canada.
Chronic autoimmune thrombocytopenic purpura (ATP) is a common hematologic
disorder in which platelet-specific autoantibodies bind to platelets and
enhance their destruction by the reticuloendothelial system. While there
has been considerable investigation of the humoral immune abnormalities in
ATP, little work has been performed on the cellular immunoregulatory
aspects of this autoimmune disorder. We describe here that patients with
ATP have lymphocytes that proliferate normally when stimulated by mitogens.
However, when stimulated by normal control platelets in 7-day
antigen-presenting cell cultures, peripheral blood mononuclear cells (PBMC)
from patients with ATP proliferate at significantly higher levels (P less
than .001) and their lymphocytes secrete significantly higher amounts of
interleukin-2 (IL- 2) (P less than .001) than do lymphocytes from control
subjects. Depletion studies with monoclonal anti-CD8 and complement did not
reduce the proliferative capacity of the responding PBMC population,
indicating that CD4+ T-helper cells may be responsible for the response.
Phenotypic analysis of peripheral blood lymphocyte subsets from patients
with ATP showed that there was a significant reduction in CD4+Leu8+ T
suppressor-inducer cells (P less than .001) and a concomitant increase in
CD3+DR+ activated T cells (P less than .001) and CD19+ B cells (P less than
.05). These data indicate that CD4+ T- helper cells from patients with ATP
are stimulated by normal platelet antigen(s) to secrete IL-2 and may
modulate the enhanced antiplatelet autoantibody response.
Volume 78,
Issue 10,
pp. 2619-2625,
11/15/1991
Copyright © 1991 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
X.-L. Zhang, J. Peng, J.-Z. Sun, J.-J. Liu, C.-S. Guo, Z.-G. Wang, Y. Yu, Y. Shi, P. Qin, S.-G. Li, et al.
De novo induction of platelet-specific CD4+CD25+ regulatory T cells from CD4+CD25- cells in patients with idiopathic thrombocytopenic purpura
Blood,
March 12, 2009;
113(11):
2568 - 2577.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Yu, S. Heck, V. Patel, J. Levan, Y. Yu, J. B. Bussel, and K. Yazdanbakhsh
Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura
Blood,
August 15, 2008;
112(4):
1325 - 1328.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Olsson, B. Ridell, L. Carlsson, S. Jacobsson, and H. Wadenvik
Recruitment of T cells into bone marrow of ITP patients possibly due to elevated expression of VLA-4 and CX3CR1
Blood,
August 15, 2008;
112(4):
1078 - 1084.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Sukati, H. G. Watson, S. J. Urbaniak, and R. N. Barker
Mapping helper T-cell epitopes on platelet membrane glycoprotein IIIa in chronic autoimmune thrombocytopenic purpura
Blood,
May 15, 2007;
109(10):
4528 - 4538.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Peng, C. Liu, D. Liu, C. Ren, W. Li, Z. Wang, N. Xing, C. Xu, X. Chen, C. Ji, et al.
Effects of B7-blocking agent and/or CsA on induction of platelet-specific T-cell anergy in chronic autoimmune thrombocytopenic purpura
Blood,
April 1, 2003;
101(7):
2721 - 2726.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Mouzaki, M. Theodoropoulou, I. Gianakopoulos, V. Vlaha, M.-C. Kyrtsonis, and A. Maniatis
Expression patterns of Th1 and Th2 cytokine genes in childhood idiopathic thrombocytopenic purpura (ITP) at presentation and their modulation by intravenous immunoglobulin G (IVIg) treatment: their role in prognosis
Blood,
August 13, 2002;
100(5):
1774 - 1779.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kuwana, J. Kaburaki, H. Kitasato, M. Kato, S. Kawai, Y. Kawakami, and Y. Ikeda
Immunodominant epitopes on glycoprotein IIb-IIIa recognized by autoreactive T cells in patients with immune thrombocytopenic purpura
Blood,
July 1, 2001;
98(1):
130 - 139.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Nomura, T. Matsuzaki, Y. Ozaki, M. Yamaoka, C. Yoshimura, K. Katsura, G. L. Xie, H. Kagawa, T. Ishida, and S. Fukuhara
Clinical Significance of HLA-DRB1*0410 in Japanese Patients With Idiopathic Thrombocytopenic Purpura
Blood,
May 15, 1998;
91(10):
3616 - 3622.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
