|
|
 Previous Article | Table of Contents | Next Article 
Immunolocalization of the Bcl-2 protein within hematopoietic neoplasms
M Zutter, D Hockenbery, GA Silverman and SJ Korsmeyer
Department of Medicine, Howard Hughes Medical Institute, Washington
University School of Medicine, St Louis, MO 63110.
The Bcl-2 proto-oncogene was discovered at the t(14;18) breakpoint found in
most follicular B-cell lymphomas and some diffuse large-cell lymphomas.
Bcl-2 is unique among proto-oncogenes, being localized to mitochondria and
extending cell survival by blocking programmed cell death. We examined
Bcl-2 protein expression in 82 hematologic malignancies and reactive
lymphoid processes. All lymphomas with Bcl-2 rearrangement demonstrated
high levels of Bcl-2 protein. However, most follicular and diffuse
lymphomas without Bcl-2 rearrangement also displayed intense Bcl-2
staining. In these cases, mechanisms other than classic translocation may
be deregulation Bcl-2. The pattern of Bcl-2 staining in follicular lymphoma
is the inverse of the pattern in reactive hyperplasia, confirming a role
for Bcl-2 immunolocalization in routine diagnosis. Small lymphocytic
malignancies, including small lymphocytic lymphoma, mantle zone lymphoma,
and chronic lymphocytic leukemia, expressed intermediate levels of Bcl-2.
Bcl-2 protein varied in plasma cell dyscrasias. Bcl-2 protein levels in
T-cell lymphomas reflected their corresponding stage of development. No
substantial Bcl- 2 was present in the Reed-Sternberg cells of nodular
sclerosing Hodgkin's disease. Chronic myelogenous leukemia was strongly
positive for Bcl-2, consistent with the presence of Bcl-2 in normal myeloid
progenitors. Immunohistochemistry identified an expanded spectrum of
hematopoietic neoplasms in which Bcl-2 may provide a cell survival
advantage.
Volume 78,
Issue 4,
pp. 1062-1068,
08/15/1991
Copyright © 1991 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
F. Luciano, M. Krajewska, P. Ortiz-Rubio, S. Krajewski, D. Zhai, B. Faustin, J.-M. Bruey, B. Bailly-Maitre, A. Lichtenstein, S. K. Kolluri, et al.
Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma
Blood,
May 1, 2007;
109(9):
3849 - 3855.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Ben-Bassat, Z. Hartzstark, R. Levitzki, B. Y. Klein, Z. Shlomai, A. Gazit, and A. Levitzki
Tyrosine Kinase Inhibitors Suppress the Growth of Non-Hodgkin B Lymphomas
J. Pharmacol. Exp. Ther.,
October 1, 2002;
303(1):
163 - 171.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. C. Briggs, R. S. Levine, L. D. Bobo, W. P. Haliburton, E. A. Brann, and C. H. Hennekens
Wine Drinking and Risk of Non-Hodgkin's Lymphoma among Men in the United States: A Population-based Case-Control Study
Am. J. Epidemiol.,
September 1, 2002;
156(5):
454 - 462.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. B. Lorsbach, D. Shay-Seymore, J. Moore, P. M. Banks, R. P. Hasserjian, J. T. Sandlund, and F. G. Behm
Clinicopathologic analysis of follicular lymphoma occurring in children
Blood,
March 15, 2002;
99(6):
1959 - 1964.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. N. Winter, J. Andersen, J. C. Reed, S. Krajewski, D. Variakojis, K. D. Bauer, R. I. Fisher, L. I. Gordon, M. M. Oken, S. Jiang, et al.
BCL-2 Expression Correlates With Lower Proliferative Activity in the Intermediate- and High-Grade Non-Hodgkin's Lymphomas: An Eastern Cooperative Oncology Group and Southwest Oncology Group Cooperative Laboratory Study
Blood,
February 15, 1998;
91(4):
1391 - 1398.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. H. Kaufmann, J. E. Karp, P. A. Svingen, S. Krajewski, P. J. Burke, S. D. Gore, and J. C. Reed
Elevated Expression of the Apoptotic Regulator Mcl-1 at the Time of Leukemic Relapse
Blood,
February 1, 1998;
91(3):
991 - 1000.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q. Lu, A. Hanby, M. Nasser Hajibagheri, S. Gschmeissner, P. Lu, J Taylor-Papadimitriou, S Krajewski, J. Reed, and N. Wright
Bcl-2 protein localizes to the chromosomes of mitotic nuclei and is correlated with the cell cycle in cultured epithelial cell lines
J. Cell Sci.,
January 2, 1994;
107(2):
363 - 371.
[Abstract]
[PDF]
|
|
|
|
|
|
|
The International Non-Hodgkin's Lymphoma Prognosti
A Predictive Model for Aggressive Non-Hodgkin's Lymphoma
N. Engl. J. Med.,
September 30, 1993;
329(14):
987 - 994.
[Abstract]
[Full Text]
|
|
|
|
|
