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Ig VH gene expression among human follicular lymphomas
DW Bahler, MJ Campbell, S Hart, RA Miller, S Levy and R Levy
Department of Medicine, Stanford University School of Medicine, CA.
Thirty-six randomly selected cases of low grade follicular lymphoma (FL)
were analyzed for Ig heavy chain variable region (VH) gene expression.
Assignment to one of the six human VH gene families (VH1 to VH6) was made
with a polymerase chain reaction-based technique using family-specific
leader primers. The frequency of VH family use in FL was found to be
similar to that reported for normal peripheral blood lymphocytes and is
therefore also roughly proportional to VH family size. To evaluate
expression within an individual family, all of the lymphoma VH genes from
the middle size VH4 family were sequenced and compared with previously
published sequences. Of these eight lymphoma VH sequences, six were most
closely related to just two of the 10 known functional VH4 germline genes.
Nonrandom usage by FL of the JH3, JH4, and JH5 joining segments was also
observed. Nucleotide sequences were also determined for 10 randomly
selected lymphoma VH genes from the large VH3 family. With one possible
exception, none of these lymphoma VH sequences appear to represent any of
the VH3 genes that may be preferentially used in the fetal repertoire.
Volume 78,
Issue 6,
pp. 1561-1568,
09/15/1991
Copyright © 1991 by The American Society of Hematology
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