|
|
 Previous Article | Table of Contents | Next Article 
Decreased CD45RA T cells in B-cell chronic lymphatic leukemia patients:
correlation with disease stage
S Peller and S Kaufman
Department of Hematology, Assaf Harofeh Medical Center, Affiliated to
Sackler Faculty of Medicine, Tel Aviv University, Zerifin, Israel.
T-cell subsets CD4, CD8 and suppressor-inducers (CD45RA) were determined in
20 patients with B-cell chronic lymphatic leukemia (B- CLL). The proportion
of CD4 and CD45RA was decreased when compared with T cells from normal
subjects. CD8 was markedly increased. The activity of concanavalin
A-induced suppressor cells was not significantly different from that of
normal controls and was negatively correlated to the percentage of CD4 of
B-CLL patients. The selective loss of CD45RA cells was more prominent in
patients in advanced Rai stages of the disease (III to IV) than in early
stages (0 to II). Six patients of the advanced stages group suffered from
autoimmune hemolytic anemia, whereas no patient in the early stages of
disease showed an autoimmune phenomenon. Our results may indicate a
mechanism of autoimmunity in B- CLL similar to that of patients with
autoimmune diseases.
Volume 78,
Issue 6,
pp. 1569-1573,
09/15/1991
Copyright © 1991 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
S. N. O'Brien, N. M.A. Blijlevens, T. H. Mahfouz, and E. J. Anaissie
Infections in Patients with Hematological Cancer: Recent Developments
Hematology,
January 1, 2003;
2003(1):
438 - 472.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Tinhofer, I. Marschitz, M. Kos, T. Henn, A. Egle, A. Villunger, and R. Greil
Differential Sensitivity of CD4+ and CD8+ T Lymphocytes to the Killing Efficacy of Fas (Apo-1/CD95) Ligand+ Tumor Cells in B Chronic Lymphocytic Leukemia
Blood,
June 1, 1998;
91(11):
4273 - 4281.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Consoli, I. El-Tounsi, A. Sandoval, V. Snell, H.-D. Kleine, W. Brown, J. R. Robinson, F. DiRaimondo, W. Plunkett, and M. Andreeff
Differential Induction of Apoptosis by Fludarabine Monophosphate in Leukemic B and Normal T Cells in Chronic Lymphocytic Leukemia
Blood,
March 1, 1998;
91(5):
1742 - 1748.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
